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Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review

This study is aimed to conduct a systematic literature review regarding the associations between psychiatric symptoms, functional impairments, and quality of life in patients with CMT (Charcot–Marie–Tooth). The PUBMED, PsycInfo, SCIELO, and LILACS electronic databases were used, and the following se...

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Autores principales: Cordeiro, Joana L.C., Marques, Wilson, Hallak, Jaime E.C., Osório, Flávia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Neurochemistry 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034707/
https://www.ncbi.nlm.nih.gov/pubmed/24654889
http://dx.doi.org/10.1042/AN20130048
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author Cordeiro, Joana L.C.
Marques, Wilson
Hallak, Jaime E.C.
Osório, Flávia L.
author_facet Cordeiro, Joana L.C.
Marques, Wilson
Hallak, Jaime E.C.
Osório, Flávia L.
author_sort Cordeiro, Joana L.C.
collection PubMed
description This study is aimed to conduct a systematic literature review regarding the associations between psychiatric symptoms, functional impairments, and quality of life in patients with CMT (Charcot–Marie–Tooth). The PUBMED, PsycInfo, SCIELO, and LILACS electronic databases were used, and the following search terms were employed: CMT, HMSN (hereditary motor and sensory neuropathy), mental disorder, quality of life, psychiatry, psychiatric, and psychological without the use of time-limit filters. According to the adopted inclusion criteria, 20 studies were included and appraised. These studies indicated that patients with CMT exhibited an increased trend toward depressive symptoms compared with the general population. In addition, CMT patients were exposed to a higher risk of reduced quality of life and significant sleep impairment. Considering the comorbidity of CMT with other psychiatric disorders, the heterogeneity of the instruments used to evaluate the psychiatric symptoms compromised the ability to compare the studies examined. Our results indicate a need for a systematic evaluation of these conditions to minimize the impairments and decreased quality of life caused by CMT.
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spelling pubmed-40347072014-06-04 Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review Cordeiro, Joana L.C. Marques, Wilson Hallak, Jaime E.C. Osório, Flávia L. ASN Neuro Research Article This study is aimed to conduct a systematic literature review regarding the associations between psychiatric symptoms, functional impairments, and quality of life in patients with CMT (Charcot–Marie–Tooth). The PUBMED, PsycInfo, SCIELO, and LILACS electronic databases were used, and the following search terms were employed: CMT, HMSN (hereditary motor and sensory neuropathy), mental disorder, quality of life, psychiatry, psychiatric, and psychological without the use of time-limit filters. According to the adopted inclusion criteria, 20 studies were included and appraised. These studies indicated that patients with CMT exhibited an increased trend toward depressive symptoms compared with the general population. In addition, CMT patients were exposed to a higher risk of reduced quality of life and significant sleep impairment. Considering the comorbidity of CMT with other psychiatric disorders, the heterogeneity of the instruments used to evaluate the psychiatric symptoms compromised the ability to compare the studies examined. Our results indicate a need for a systematic evaluation of these conditions to minimize the impairments and decreased quality of life caused by CMT. American Society for Neurochemistry 2014-05-27 /pmc/articles/PMC4034707/ /pubmed/24654889 http://dx.doi.org/10.1042/AN20130048 Text en © 2014 The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Licence (CC-BY)(http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cordeiro, Joana L.C.
Marques, Wilson
Hallak, Jaime E.C.
Osório, Flávia L.
Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title_full Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title_fullStr Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title_full_unstemmed Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title_short Charcot–Marie–Tooth disease, psychiatric indicators and quality of life: a systematic review
title_sort charcot–marie–tooth disease, psychiatric indicators and quality of life: a systematic review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034707/
https://www.ncbi.nlm.nih.gov/pubmed/24654889
http://dx.doi.org/10.1042/AN20130048
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