Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.

[Image: see text] Three new acylated arylamine derivatives (1–3), carpatamides A–C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1–3 were established on the basis of comprehensive spectroscopic analyses...

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Autores principales: Fu, Peng, Johnson, Melissa, Chen, Hong, Posner, Bruce A., MacMillan, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035114/
https://www.ncbi.nlm.nih.gov/pubmed/24754815
http://dx.doi.org/10.1021/np500207p
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author Fu, Peng
Johnson, Melissa
Chen, Hong
Posner, Bruce A.
MacMillan, John B.
author_facet Fu, Peng
Johnson, Melissa
Chen, Hong
Posner, Bruce A.
MacMillan, John B.
author_sort Fu, Peng
collection PubMed
description [Image: see text] Three new acylated arylamine derivatives (1–3), carpatamides A–C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1–3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC(50) values ranging from 2.2 to 8.4 μM.
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spelling pubmed-40351142015-04-23 Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp. Fu, Peng Johnson, Melissa Chen, Hong Posner, Bruce A. MacMillan, John B. J Nat Prod [Image: see text] Three new acylated arylamine derivatives (1–3), carpatamides A–C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1–3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC(50) values ranging from 2.2 to 8.4 μM. American Chemical Society and American Society of Pharmacognosy 2014-04-23 2014-05-23 /pmc/articles/PMC4035114/ /pubmed/24754815 http://dx.doi.org/10.1021/np500207p Text en Copyright © 2014 American Chemical Society and American Society of Pharmacognosy
spellingShingle Fu, Peng
Johnson, Melissa
Chen, Hong
Posner, Bruce A.
MacMillan, John B.
Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title_full Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title_fullStr Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title_full_unstemmed Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title_short Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp.
title_sort carpatamides a–c, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035114/
https://www.ncbi.nlm.nih.gov/pubmed/24754815
http://dx.doi.org/10.1021/np500207p
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