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Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza

Severe influenza is characterized by cytokine storm and multiorgan failure with metabolic energy disorders and vascular hyperpermeability. In the regulation of energy homeostasis, the pyruvate dehydrogenase (PDH) complex plays an important role by catalyzing oxidative decarboxylation of pyruvate, li...

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Detalles Bibliográficos
Autores principales:	Yamane, Kazuhiko, Indalao, Irene L., Chida, Junji, Yamamoto, Yoshikazu, Hanawa, Masaaki, Kido, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035290/ https://www.ncbi.nlm.nih.gov/pubmed/24865588 http://dx.doi.org/10.1371/journal.pone.0098032

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