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Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice

Prion disease is caused by a single pathogenic protein (PrP(Sc)), an abnormal conformer of the normal cellular prion protein PrP(C). Depletion of PrP(C) in prion knockout mice makes them resistant to prion disease. Thus, gene silencing of the Prnp gene is a promising effective therapeutic approach....

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Detalles Bibliográficos
Autores principales:	Ahn, Misol, Bajsarowicz, Krystyna, Oehler, Abby, Lemus, Azucena, Bankiewicz, Krystof, DeArmond, Stephen J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035323/ https://www.ncbi.nlm.nih.gov/pubmed/24866748 http://dx.doi.org/10.1371/journal.pone.0098496

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