The core and conserved role of MAL is homeostatic regulation of actin levels

The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and...

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Detalles Bibliográficos
Autores principales: Salvany, Lara, Muller, Julius, Guccione, Ernesto, Rørth, Pernille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035534/
https://www.ncbi.nlm.nih.gov/pubmed/24831700
http://dx.doi.org/10.1101/gad.237743.114
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author Salvany, Lara
Muller, Julius
Guccione, Ernesto
Rørth, Pernille
author_facet Salvany, Lara
Muller, Julius
Guccione, Ernesto
Rørth, Pernille
author_sort Salvany, Lara
collection PubMed
description The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and human cellular models that actin is the key target that must be regulated by MAL/SRF for invasive cell migration. By regulating MAL/SRF activity, actin protein feeds back on production of actin mRNA to ensure sufficient supply of actin. This constitutes a dedicated homeostatic feedback system that provides a foundation for cellular actin dynamics.
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spelling pubmed-40355342014-11-15 The core and conserved role of MAL is homeostatic regulation of actin levels Salvany, Lara Muller, Julius Guccione, Ernesto Rørth, Pernille Genes Dev Research Communication The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and human cellular models that actin is the key target that must be regulated by MAL/SRF for invasive cell migration. By regulating MAL/SRF activity, actin protein feeds back on production of actin mRNA to ensure sufficient supply of actin. This constitutes a dedicated homeostatic feedback system that provides a foundation for cellular actin dynamics. Cold Spring Harbor Laboratory Press 2014-05-15 /pmc/articles/PMC4035534/ /pubmed/24831700 http://dx.doi.org/10.1101/gad.237743.114 Text en © 2014 Salvany et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Research Communication
Salvany, Lara
Muller, Julius
Guccione, Ernesto
Rørth, Pernille
The core and conserved role of MAL is homeostatic regulation of actin levels
title The core and conserved role of MAL is homeostatic regulation of actin levels
title_full The core and conserved role of MAL is homeostatic regulation of actin levels
title_fullStr The core and conserved role of MAL is homeostatic regulation of actin levels
title_full_unstemmed The core and conserved role of MAL is homeostatic regulation of actin levels
title_short The core and conserved role of MAL is homeostatic regulation of actin levels
title_sort core and conserved role of mal is homeostatic regulation of actin levels
topic Research Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035534/
https://www.ncbi.nlm.nih.gov/pubmed/24831700
http://dx.doi.org/10.1101/gad.237743.114
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