Global microRNA depletion suppresses tumor angiogenesis

MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signalin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Sidi, Xue, Yuan, Wu, Xuebing, Le, Cong, Bhutkar, Arjun, Bell, Eric L., Zhang, Feng, Langer, Robert, Sharp, Phillip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035535/
https://www.ncbi.nlm.nih.gov/pubmed/24788094
http://dx.doi.org/10.1101/gad.239681.114

Ejemplares similares

Ejemplares similares