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Investigating the Impact of Asp181 Point Mutations on Interactions between PTP1B and Phosphotyrosine Substrate

Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin and leptin signaling, which suggests that it is an attractive therapeutic target in type II diabetes and obesity. The aim of this research is to explore residues which interact with phosphotyrosine substrate can be affect...

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Detalles Bibliográficos
Autores principales:	Liu, Mengyuan, Wang, Lushan, Sun, Xun, Zhao, Xian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035576/ https://www.ncbi.nlm.nih.gov/pubmed/24865376 http://dx.doi.org/10.1038/srep05095

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