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Ubiquitin ligase ITCH recruitment suppresses the aggregation and cellular toxicity of cytoplasmic misfolded proteins

The protein quality control (QC) system protects cells against cellular toxicity induced by misfolded proteins and maintains overall cellular fitness. Inefficient clearance of or failure to degrade damaged proteins causes several diseases, especially age-linked neurodegenerative disorders. Attenuati...

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Detalles Bibliográficos
Autores principales:	Chhangani, Deepak, Upadhyay, Arun, Amanullah, Ayeman, Joshi, Vibhuti, Mishra, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035578/ https://www.ncbi.nlm.nih.gov/pubmed/24865853 http://dx.doi.org/10.1038/srep05077

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