Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer's glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD(+)) from reduced nicotinamide adenine dinucleotide (NADH) necessary to sustain...

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Detalles Bibliográficos
Autores principales: Allison, S J, Knight, J R P, Granchi, C, Rani, R, Minutolo, F, Milner, J, Phillips, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035693/
https://www.ncbi.nlm.nih.gov/pubmed/24819061
http://dx.doi.org/10.1038/oncsis.2014.16

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