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3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging
BACKGROUND: The treatment of microcirculatory impairment will have great impact if it can be applied to myocardial infarction (MI) patients. The problem is how to study these tiny structures and microphenomenon in heart. METHODS: We investigated the visualization of cardiac microvessels embolization...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035802/ https://www.ncbi.nlm.nih.gov/pubmed/24886327 http://dx.doi.org/10.1186/1475-925X-13-62 |
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author | Zhang, Lu Wang, Ke Zheng, Fei Li, Xia Luo, Shuqian |
author_facet | Zhang, Lu Wang, Ke Zheng, Fei Li, Xia Luo, Shuqian |
author_sort | Zhang, Lu |
collection | PubMed |
description | BACKGROUND: The treatment of microcirculatory impairment will have great impact if it can be applied to myocardial infarction (MI) patients. The problem is how to study these tiny structures and microphenomenon in heart. METHODS: We investigated the visualization of cardiac microvessels embolization by the mean of X-ray phase contrast imaging (XPCI), which is a recently emerged imaging technique. Using the information of X-ray phase shift, it is sensitive to weak absorbing materials. Two MI SD rats were used as the microvessel embolization samples. MI was surgically induced by ligating left anterior descending artery. Imaging was performed 24 hours post-infarct, with barium sulfate as contrast agent. RESULTS: The coronary arteries were visualized with smooth walls and clear edges. The ligated vessels, with the diameter of about three hundred microns, can be clearly distinguished and there were no distal blood flow downstream from these branches. The results indicate that phase contrast imaging can directly demonstrate the distribution of microvessels, and estimate the area of MI. The infarct location was in good agreement with pathological analyses of the models. CONCLUSIONS: The advantage of our method is directly observing and evaluating microvessel embolization which simplifies the procedure of diagnoses. Moreover, it is helpful for predicting the prognosis in MI and judging if angiogenesis happens. |
format | Online Article Text |
id | pubmed-4035802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40358022014-05-29 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging Zhang, Lu Wang, Ke Zheng, Fei Li, Xia Luo, Shuqian Biomed Eng Online Research BACKGROUND: The treatment of microcirculatory impairment will have great impact if it can be applied to myocardial infarction (MI) patients. The problem is how to study these tiny structures and microphenomenon in heart. METHODS: We investigated the visualization of cardiac microvessels embolization by the mean of X-ray phase contrast imaging (XPCI), which is a recently emerged imaging technique. Using the information of X-ray phase shift, it is sensitive to weak absorbing materials. Two MI SD rats were used as the microvessel embolization samples. MI was surgically induced by ligating left anterior descending artery. Imaging was performed 24 hours post-infarct, with barium sulfate as contrast agent. RESULTS: The coronary arteries were visualized with smooth walls and clear edges. The ligated vessels, with the diameter of about three hundred microns, can be clearly distinguished and there were no distal blood flow downstream from these branches. The results indicate that phase contrast imaging can directly demonstrate the distribution of microvessels, and estimate the area of MI. The infarct location was in good agreement with pathological analyses of the models. CONCLUSIONS: The advantage of our method is directly observing and evaluating microvessel embolization which simplifies the procedure of diagnoses. Moreover, it is helpful for predicting the prognosis in MI and judging if angiogenesis happens. BioMed Central 2014-05-21 /pmc/articles/PMC4035802/ /pubmed/24886327 http://dx.doi.org/10.1186/1475-925X-13-62 Text en Copyright © 2014 Zhang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Zhang, Lu Wang, Ke Zheng, Fei Li, Xia Luo, Shuqian 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title | 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title_full | 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title_fullStr | 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title_full_unstemmed | 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title_short | 3D Cardiac microvessels embolization imaging based on X-ray phase contrast imaging |
title_sort | 3d cardiac microvessels embolization imaging based on x-ray phase contrast imaging |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035802/ https://www.ncbi.nlm.nih.gov/pubmed/24886327 http://dx.doi.org/10.1186/1475-925X-13-62 |
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