Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1(G93A) ALS mice: overlapping effects or limited therapeutic opportunity?

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (MNs) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. Nowadays, there is no effective therapy and most patients die 2–5 years...

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Detalles Bibliográficos
Autores principales: Mancuso, Renzo, del Valle, Jaume, Morell, Marta, Pallás, Mercé, Osta, Rosario, Navarro, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035830/
https://www.ncbi.nlm.nih.gov/pubmed/24885036
http://dx.doi.org/10.1186/1750-1172-9-78

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