Cargando…

Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma

Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shao, Ruijin, Li, Xin, Feng, Yi, Lin, Jin-Fang, Billig, Håkan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036091/ https://www.ncbi.nlm.nih.gov/pubmed/24887156 http://dx.doi.org/10.1186/1756-9966-33-41

Ejemplares similares

Promising clinical practices of metformin in women with PCOS and early-stage endometrial cancer
por: Shao, Ruijin, et al.
Publicado: (2014)

Combination of Diane-35 and Metformin to Treat Early Endometrial Carcinoma in PCOS Women with Insulin Resistance
por: Li, Xin, et al.
Publicado: (2014)

Endometrial progesterone resistance and PCOS
por: Li, Xin, et al.
Publicado: (2014)

Lack of cyclical fluctuations of endometrial GLUT4 expression in women with polycystic ovary syndrome: Evidence for direct regulation of GLUT4 by steroid hormones
por: Cui, Peng, et al.
Publicado: (2015)

Differential Expression Patterns of Glycolytic Enzymes and Mitochondria-Dependent Apoptosis in PCOS Patients with Endometrial Hyperplasia, an Early Hallmark of Endometrial Cancer, In Vivo and the Impact of Metformin In Vitro
por: Wang, Tao, et al.
Publicado: (2019)

Regulation of Androgen Receptor Expression Alters AMPK Phosphorylation in the Endometrium: In Vivo and In Vitro Studies in Women with Polycystic Ovary Syndrome
por: Li, Xin, et al.
Publicado: (2015)

Quantitative analysis of hormones and inflammatory cytokines in Chlamydia trachomatis-infected women with tubal ectopic pregnancy and early intrauterine pregnancy
por: Shao, Ruijin, et al.
Publicado: (2015)

Immunomodulatory Effects of Metformin Treatment in Pregnant Women With PCOS
por: Ryssdal, Mariell, et al.
Publicado: (2023)

Direct Cell–Cell Interactions in the Endometrium and in Endometrial Pathophysiology
por: Grund, Susanne, et al.
Publicado: (2018)

Metformin-Clinical Pharmacology in PCOs
por: Dumitrescu, R, et al.
Publicado: (2015)

The Use of Ceramides to Predict Metabolic Response to Metformin in Women With PCOS
por: Sharma, Anu, et al.
Publicado: (2022)

Progesterone receptor isoforms A and B: new insights into the mechanism of progesterone resistance for the treatment of endometrial carcinoma
por: Shao, Ruijin
Publicado: (2013)

Comparison of the diagnostic values of circulating steroid hormones, VEGF-A, PIGF, and ADAM12 in women with ectopic pregnancy
por: Zou, Shien, et al.
Publicado: (2013)

PMON209 Ceramides Predict Metabolic Response to Metformin in Women with PCOS
por: Sharma, Anu, et al.
Publicado: (2022)

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium
por: Bartosch, Carla, et al.
Publicado: (2015)

Metformin Ameliorates Uterine Defects in a Rat Model of Polycystic Ovary Syndrome
por: Zhang, Yuehui, et al.
Publicado: (2017)

Pathological pattern of endometrial abnormalities in postmenopausal women with bleeding or thickened endometrium
por: Xue, Hui, et al.
Publicado: (2022)

Are women with PCOS more at risk for endometrial cancer? What approach for such patients?
por: Vladislava Valerievna, Khalenko, et al.
Publicado: (2023)

Evaluation of the effect of metformin and aspirin on utero placental circulation of pregnant women with PCOS
por: Jamal, Ashraf, et al.
Publicado: (2012)

Diagnosing Endometrial Carcinoma in a Patient With Atrophic Endometrium and Postmenopausal Bleeding
por: Prabhakaran, Madhumitha, et al.
Publicado: (2022)

The function of metformin in endometrial receptivity (ER) of patients with polycyclic ovary syndrome (PCOS): a systematic review and meta-analysis
por: Yuan, Lifang, et al.
Publicado: (2021)

β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota
por: Yu, Yanyan, et al.
Publicado: (2021)

Incidental Finding of Thickened Endometrium in Postmenopausal Women: A Survey of Endometrial Cancer
por: Quaranta, Michela, et al.
Publicado: (2023)

Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism
por: Poh, Sharon Shuxian, et al.
Publicado: (2016)

Progesterone-mediated effects on gene expression and oocyte-cumulus complex transport in the mouse fallopian tube
por: Bylander, Anna, et al.
Publicado: (2015)

Diane-35 and Metformin Induce Autophagy and Apoptosis in Polycystic Ovary Syndrome Women with Early-Stage Endometrial Carcinoma
por: Liu, Yanjun, et al.
Publicado: (2022)

Pathological findings in the endometrium after microwave endometrial ablation
por: Nakayama, Kentaro, et al.
Publicado: (2020)

Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility
por: Attia, Ghalia M, et al.
Publicado: (2023)

Metformin-letrozole in comparison with Metformin-clomiphene citrate in clomiphene-resistance PCOS patients undergoing IUI
por: Davar, Robab, et al.
Publicado: (2011)

Effect of metformin on proliferative markers in women with endometrial carcinoma: Systematic review and meta-analysis
por: Shareef, Mohammad Abrar, et al.
Publicado: (2022)

Expression of nodal signalling components in cycling human endometrium and in endometrial cancer
por: Papageorgiou, Irene, et al.
Publicado: (2009)

Serum and follicular anti-Mullerian hormone levels in women with polycystic ovary syndrome (PCOS) under metformin
por: Falbo, Angela, et al.
Publicado: (2010)

Endometrial carcinoma in asymptomatic post-menopausal women with a thickened endometrium and its influencing factors - A cross-sectional study
por: Pegu, Bhabani, et al.
Publicado: (2022)

Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions
por: Drizi, Amal, et al.
Publicado: (2020)

Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma
por: Ouyang, Zhuo, et al.
Publicado: (2019)

Collagen and Eosinophils in Jenny's Endometrium: Do They Differ With Endometrial Classification?
por: Miró, Jordi, et al.
Publicado: (2020)

The Importance of the Correlation between the Ultrasonographic Evaluation of Endometrium and Histopathological Findings in Patients with Endometrial Hyperplasia and Carcinoma
por: STOENESCU, V., et al.
Publicado: (2017)

Clear Cell Carcinoma of the Endometrium in a Patient Presenting with Postmenopausal Bleeding but Negative Endometrial Biopsy
por: Silwal, Swechchha, et al.
Publicado: (2021)

Hypothalamic Neuroendocrine Functions in Rats with Dihydrotestosterone-Induced Polycystic Ovary Syndrome: Effects of Low-Frequency Electro-Acupuncture
por: Feng, Yi, et al.
Publicado: (2009)

Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study
por: Furat Rencber, Selenay, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_refgmknjp1dejocp3kj645eggb