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Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins
We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did no...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036137/ https://www.ncbi.nlm.nih.gov/pubmed/24926228 http://dx.doi.org/10.1159/000362440 |
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author | Tomino, Takahiro Yamashita, Yo-ichi Iguchi, Tomohiro Itoh, Shinji Ninomiya, Mizuki Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Kawanaka, Hirofumi Ikeda, Tetsuo Aishima, Shinichi Shirabe, Ken Maehara, Yoshihiko |
author_facet | Tomino, Takahiro Yamashita, Yo-ichi Iguchi, Tomohiro Itoh, Shinji Ninomiya, Mizuki Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Kawanaka, Hirofumi Ikeda, Tetsuo Aishima, Shinichi Shirabe, Ken Maehara, Yoshihiko |
author_sort | Tomino, Takahiro |
collection | PubMed |
description | We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it. |
format | Online Article Text |
id | pubmed-4036137 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-40361372014-06-12 Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins Tomino, Takahiro Yamashita, Yo-ichi Iguchi, Tomohiro Itoh, Shinji Ninomiya, Mizuki Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Kawanaka, Hirofumi Ikeda, Tetsuo Aishima, Shinichi Shirabe, Ken Maehara, Yoshihiko Case Rep Gastroenterol Published online: April, 2014 We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it. S. Karger AG 2014-04-24 /pmc/articles/PMC4036137/ /pubmed/24926228 http://dx.doi.org/10.1159/000362440 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: April, 2014 Tomino, Takahiro Yamashita, Yo-ichi Iguchi, Tomohiro Itoh, Shinji Ninomiya, Mizuki Ikegami, Toru Yoshizumi, Tomoharu Soejima, Yuji Kawanaka, Hirofumi Ikeda, Tetsuo Aishima, Shinichi Shirabe, Ken Maehara, Yoshihiko Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title | Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title_full | Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title_fullStr | Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title_full_unstemmed | Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title_short | Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins |
title_sort | spontaneous massive necrosis of hepatocellular carcinoma with narrowing and occlusion of the arteries and portal veins |
topic | Published online: April, 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036137/ https://www.ncbi.nlm.nih.gov/pubmed/24926228 http://dx.doi.org/10.1159/000362440 |
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