Small Molecule-facilitated Degradation of ANO1 Protein: A NEW TARGETING APPROACH FOR ANTICANCER THERAPEUTICS

ANO1, a calcium-activated chloride channel, is highly expressed and amplified in human cancers and is a critical survival factor in these cancers. The ANO1 inhibitor CaCC(inh)-A01 decreases proliferation of ANO1-amplified cell lines; however, the mechanism of action remains elusive. We explored the...

Descripción completa

Detalles Bibliográficos
Autores principales: Bill, Anke, Hall, Michelle Lynn, Borawski, Jason, Hodgson, Catherine, Jenkins, Jeremy, Piechon, Philippe, Popa, Oana, Rothwell, Christopher, Tranter, Pamela, Tria, Scott, Wagner, Trixie, Whitehead, Lewis, Gaither, L. Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036244/
https://www.ncbi.nlm.nih.gov/pubmed/24599954
http://dx.doi.org/10.1074/jbc.M114.549188

Ejemplares similares

Ejemplares similares