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Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction
OBJECTIVES: Although many clinical and experimental investigations have shed light on muscle atrophy and intramuscular accumulation of fat after rotator cuff disruption, none have reported on their onset in the absence of muscle retraction. METHODS: In 30 rabbits, we detached one supraspinatus (SSP)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
British Editorial Society of Bone and Joint Surgery
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036302/ https://www.ncbi.nlm.nih.gov/pubmed/24743593 http://dx.doi.org/10.1302/2046-3758.34.2000275 |
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author | Uhthoff, H. K. Coletta, E. Trudel, G. |
author_facet | Uhthoff, H. K. Coletta, E. Trudel, G. |
author_sort | Uhthoff, H. K. |
collection | PubMed |
description | OBJECTIVES: Although many clinical and experimental investigations have shed light on muscle atrophy and intramuscular accumulation of fat after rotator cuff disruption, none have reported on their onset in the absence of muscle retraction. METHODS: In 30 rabbits, we detached one supraspinatus (SSP) tendon and repaired it immediately, thus preventing muscle retraction. The animals were killed in groups of 10 at one, two and six weeks. Both shoulders of 15 non-operated rabbits served as controls. We measured the weight and volume of SSP muscles and quantified the cross-sectional area of intramuscular fat (i-fat) histologically. RESULTS: There was significant loss of muscle weight and volume after one week (p = 0.004 and 0.003, respectively), and two weeks (both p < 0.001) in the experimental group; which recovered to control values after six weeks. I-fat accumulated one week after immediate repair, greater than in the control group and statistically significant at the mid-part of the muscle (mean 2.7% vs 1.5%, p = 0.008). I-fat continued to accumulate up to six weeks at all sites of the SSP muscle (all 3, p < 0.001). More fat accumulated closer to the musculotendinous junction than at the mid-part after two and six weeks (p = 0.012 and 0.019, respectively). CONCLUSION: Muscle atrophy and i-fat accumulation occur early after SSP tendon tear and immediate repair. While early repair benefitted muscle recovery, it did not prevent fat accumulation. SSP muscle retraction was not essential to the muscle alterations. The divergent evolution of muscle and fat points to different pathophysiologies. |
format | Online Article Text |
id | pubmed-4036302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | British Editorial Society of Bone and Joint Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-40363022014-06-02 Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction Uhthoff, H. K. Coletta, E. Trudel, G. Bone Joint Res Shoulder & Elbow OBJECTIVES: Although many clinical and experimental investigations have shed light on muscle atrophy and intramuscular accumulation of fat after rotator cuff disruption, none have reported on their onset in the absence of muscle retraction. METHODS: In 30 rabbits, we detached one supraspinatus (SSP) tendon and repaired it immediately, thus preventing muscle retraction. The animals were killed in groups of 10 at one, two and six weeks. Both shoulders of 15 non-operated rabbits served as controls. We measured the weight and volume of SSP muscles and quantified the cross-sectional area of intramuscular fat (i-fat) histologically. RESULTS: There was significant loss of muscle weight and volume after one week (p = 0.004 and 0.003, respectively), and two weeks (both p < 0.001) in the experimental group; which recovered to control values after six weeks. I-fat accumulated one week after immediate repair, greater than in the control group and statistically significant at the mid-part of the muscle (mean 2.7% vs 1.5%, p = 0.008). I-fat continued to accumulate up to six weeks at all sites of the SSP muscle (all 3, p < 0.001). More fat accumulated closer to the musculotendinous junction than at the mid-part after two and six weeks (p = 0.012 and 0.019, respectively). CONCLUSION: Muscle atrophy and i-fat accumulation occur early after SSP tendon tear and immediate repair. While early repair benefitted muscle recovery, it did not prevent fat accumulation. SSP muscle retraction was not essential to the muscle alterations. The divergent evolution of muscle and fat points to different pathophysiologies. British Editorial Society of Bone and Joint Surgery 2014-04-01 /pmc/articles/PMC4036302/ /pubmed/24743593 http://dx.doi.org/10.1302/2046-3758.34.2000275 Text en ©2014 The British Editorial Society of Bone & Joint Surgery ©2014 The British Editorial Society of Bone & Joint Surgery. This is an open-access article distributed under the terms of the Creative Commons Attributions licence, which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited. |
spellingShingle | Shoulder & Elbow Uhthoff, H. K. Coletta, E. Trudel, G. Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title | Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title_full | Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title_fullStr | Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title_full_unstemmed | Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title_short | Intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
title_sort | intramuscular fat accumulation and muscle atrophy in the absence of muscle retraction |
topic | Shoulder & Elbow |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036302/ https://www.ncbi.nlm.nih.gov/pubmed/24743593 http://dx.doi.org/10.1302/2046-3758.34.2000275 |
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