Cargando…

Keeping It Simple, Transport Mechanism and pH Regulation in Na(+)/H(+) Exchangers

Na(+)/H(+) exchangers are essential for regulation of intracellular proton and sodium concentrations in all living organisms. We examined and experimentally verified a kinetic model for Na(+)/H(+) exchangers, where a single binding site is alternatively occupied by Na(+) or one or two H(+) ions. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Călinescu, Octavian, Paulino, Cristina, Kühlbrandt, Werner, Fendler, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036328/ https://www.ncbi.nlm.nih.gov/pubmed/24644283 http://dx.doi.org/10.1074/jbc.M113.542993

Ejemplares similares

Electrogenic Cation Binding in the Electroneutral Na(+)/H(+) Antiporter of Pyrococcus abyssi
por: Călinescu, Octavian, et al.
Publicado: (2016)

Lysine 300 is essential for stability but not for electrogenic transport of the Escherichia coli NhaA Na(+)/H(+) antiporter
por: Călinescu, Octavian, et al.
Publicado: (2017)

Transport Mechanism and pH Regulation of the Na(+)/H(+) Antiporter NhaA from Escherichia coli: AN ELECTROPHYSIOLOGICAL STUDY
por: Mager, Thomas, et al.
Publicado: (2011)

Differential Effects of Mutations on the Transport Properties of the Na(+)/H(+) Antiporter NhaA from Escherichia coli
por: Mager, Thomas, et al.
Publicado: (2013)

Competition is the basis of the transport mechanism of the NhaB Na(+)/H(+) exchanger from Klebsiella pneumoniae
por: Patiño-Ruiz, Miyer, et al.
Publicado: (2017)

Mutation of two key aspartate residues alters stoichiometry of the NhaB Na(+)/H(+) exchanger from Klebsiella pneumoniae
por: Patiño-Ruiz, Miyer, et al.
Publicado: (2019)

Prokaryotic Na(+)/H(+) Exchangers—Transport Mechanism and Essential Residues
por: Patiño-Ruiz, Miyer, et al.
Publicado: (2022)

Kinetic Equivalence of Transmembrane pH and Electrical Potential Differences in ATP Synthesis
por: Soga, Naoki, et al.
Publicado: (2012)

A Na(+) leak channel cloned from Trichoplax adhaerens extends extracellular pH and Ca(2+) sensing for the DEG/ENaC family close to the base of Metazoa
por: Elkhatib, Wassim, et al.
Publicado: (2019)

pH- and sodium-induced changes in a sodium/proton antiporter
por: Paulino, Cristina, et al.
Publicado: (2014)

TPC2 Is a Novel NAADP-sensitive Ca(2+) Release Channel, Operating as a Dual Sensor of Luminal pH and Ca(2+)
por: Pitt, Samantha J., et al.
Publicado: (2010)

NhaA Na(+)/H(+) Antiporter Mutants That Hardly React to the Membrane Potential
por: Alkoby, Dudu, et al.
Publicado: (2014)

Na(+)/H(+) Exchangers and Intracellular pH in Perinatal Brain Injury
por: Uria-Avellanal, Cristina, et al.
Publicado: (2014)

Unifying Concept of Serotonin Transporter-associated Currents
por: Schicker, Klaus, et al.
Publicado: (2012)

Extracellular Determinants of Anion Discrimination of the Cl(−)/H(+) Antiporter Protein CLC-5
por: De Stefano, Silvia, et al.
Publicado: (2011)

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
por: Han, Shuo, et al.
Publicado: (2022)

The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues
por: Okuda, Masahiko, et al.
Publicado: (2020)

The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters
por: Bulling, Simon, et al.
Publicado: (2012)

Cytosolic pH regulation in osteoblasts. Interaction of Na+ and H+ with the extracellular and intracellular faces of the Na+/H+ exchanger
Publicado: (1988)

A Molecular Switch between the Outer and the Inner Vestibules of the Voltage-gated Na(+) Channel
por: Zarrabi, Touran, et al.
Publicado: (2010)

Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters
por: Stolzenberg, Sebastian, et al.
Publicado: (2015)

pH regulatory Na/H exchange by Amphiuma red blood cells
Publicado: (1994)

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism
por: Li, Yang, et al.
Publicado: (2017)

A novel pH-dependent membrane peptide that binds to EphA2 and inhibits cell migration
por: Alves, Daiane S, et al.
Publicado: (2018)

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies
por: Goulet, Dennis R., et al.
Publicado: (2018)

Small Substrate Transport and Mechanism of a Molybdate ATP Binding Cassette Transporter in a Lipid Environment
por: Rice, Austin J., et al.
Publicado: (2014)

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter
por: Hasenhuetl, Peter S., et al.
Publicado: (2016)

Revealing an outward-facing open conformational state in a CLC Cl(–)/H(+) exchange transporter
por: Khantwal, Chandra M, et al.
Publicado: (2016)

5′-(CGA)(n) sequence-assisted pH-controlled assembly of supramolecular DNA nanostructure
por: Yan, Yuting, et al.
Publicado: (2018)

Intracellular pH regulation in the renal proximal tubule of the salamander. Na-H exchange
Publicado: (1983)

Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1
por: Zhao, Fan, et al.
Publicado: (2021)

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance
por: Leray, Xavier, et al.
Publicado: (2022)

Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells
por: Wildling, Linda, et al.
Publicado: (2012)

Na+-H+ exchange at the apical membrane of Necturus gallbladder. Extracellular and intracellular pH studies
Publicado: (1982)

Na(+)/H(+) Exchangers Involve in Regulating the pH-Sensitive Ion Channels in Mouse Sperm
por: Kang, Hang, et al.
Publicado: (2021)

pH-dependent 11° F(1)F(O) ATP synthase sub-steps reveal insight into the F(O) torque generating mechanism
por: Yanagisawa, Seiga, et al.
Publicado: (2021)

Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2020)

Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts
Publicado: (1995)

Molecular determinants of pH regulation in the cardiac Na(+)–Ca(2+) exchanger
por: John, Scott, et al.
Publicado: (2018)

Correction: Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jnd47qe39t0uepb4v2gvv9g6ft