Cargando…

Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)

The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) part...

Descripción completa

Detalles Bibliográficos
Autores principales: Nunes, Paulo Humberto M., Martins, Maria do Carmo C., Oliveira, Rita de Cássia M., Chaves, Mariana H., Sousa, Elcilene A., Leite, José Roberto S. A., Véras, Leiz Maria, Almeida, Fernanda Regina C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036414/
https://www.ncbi.nlm.nih.gov/pubmed/24900960
http://dx.doi.org/10.1155/2014/261745
_version_ 1782318154365534208
author Nunes, Paulo Humberto M.
Martins, Maria do Carmo C.
Oliveira, Rita de Cássia M.
Chaves, Mariana H.
Sousa, Elcilene A.
Leite, José Roberto S. A.
Véras, Leiz Maria
Almeida, Fernanda Regina C.
author_facet Nunes, Paulo Humberto M.
Martins, Maria do Carmo C.
Oliveira, Rita de Cássia M.
Chaves, Mariana H.
Sousa, Elcilene A.
Leite, José Roberto S. A.
Véras, Leiz Maria
Almeida, Fernanda Regina C.
author_sort Nunes, Paulo Humberto M.
collection PubMed
description The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have been evaluated. TFEE presented low acute toxicity, antioxidant, and antiulcerogenic activity against ethanol-induced ulcers, which was partially blocked by pretreatment with L-NAME and indomethacin. It reduced the total acidity and raised the pH of gastric secretion. Additionally, TFEE delayed gastric emptying and slightly inhibited the small intestinal transit and also presented a weakly antidiarrheal activity. The antiulcerogenic and antioxidant activity were also detected in TFAqF and TFHAF but not in TFHEXF. The antisecretory and gastroprotective activity of TFEE partially involve the nitric oxide and prostaglandin participation. Nevertheless, TFEE, TFAqF, and TFHAF drastically reduced the mucus layer adhered to the gastric wall of rats treated with ethanol or indomethacin. Complementary studies are required in order to clarify the paradox of the presence of a gastroprotector activity in this plant that, at the same time, reduces the mucus layer adhered to the gastric wall.
format Online
Article
Text
id pubmed-4036414
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40364142014-06-04 Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae) Nunes, Paulo Humberto M. Martins, Maria do Carmo C. Oliveira, Rita de Cássia M. Chaves, Mariana H. Sousa, Elcilene A. Leite, José Roberto S. A. Véras, Leiz Maria Almeida, Fernanda Regina C. Biomed Res Int Research Article The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have been evaluated. TFEE presented low acute toxicity, antioxidant, and antiulcerogenic activity against ethanol-induced ulcers, which was partially blocked by pretreatment with L-NAME and indomethacin. It reduced the total acidity and raised the pH of gastric secretion. Additionally, TFEE delayed gastric emptying and slightly inhibited the small intestinal transit and also presented a weakly antidiarrheal activity. The antiulcerogenic and antioxidant activity were also detected in TFAqF and TFHAF but not in TFHEXF. The antisecretory and gastroprotective activity of TFEE partially involve the nitric oxide and prostaglandin participation. Nevertheless, TFEE, TFAqF, and TFHAF drastically reduced the mucus layer adhered to the gastric wall of rats treated with ethanol or indomethacin. Complementary studies are required in order to clarify the paradox of the presence of a gastroprotector activity in this plant that, at the same time, reduces the mucus layer adhered to the gastric wall. Hindawi Publishing Corporation 2014 2014-05-12 /pmc/articles/PMC4036414/ /pubmed/24900960 http://dx.doi.org/10.1155/2014/261745 Text en Copyright © 2014 Paulo Humberto M. Nunes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nunes, Paulo Humberto M.
Martins, Maria do Carmo C.
Oliveira, Rita de Cássia M.
Chaves, Mariana H.
Sousa, Elcilene A.
Leite, José Roberto S. A.
Véras, Leiz Maria
Almeida, Fernanda Regina C.
Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title_full Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title_fullStr Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title_full_unstemmed Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title_short Gastric Antiulcerogenic and Hypokinetic Activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae)
title_sort gastric antiulcerogenic and hypokinetic activities of terminalia fagifolia mart. & zucc. (combretaceae)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036414/
https://www.ncbi.nlm.nih.gov/pubmed/24900960
http://dx.doi.org/10.1155/2014/261745
work_keys_str_mv AT nunespaulohumbertom gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT martinsmariadocarmoc gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT oliveiraritadecassiam gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT chavesmarianah gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT sousaelcilenea gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT leitejoserobertosa gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT verasleizmaria gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae
AT almeidafernandareginac gastricantiulcerogenicandhypokineticactivitiesofterminaliafagifoliamartzucccombretaceae