Cargando…

Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies

Regenerative medicine has reached the point where we are performing clinical trials with stem-cell-derived cell populations in an effort to treat numerous human pathologies. However, many of these efforts have been challenged by the inability of the engrafted populations to properly integrate into t...

Descripción completa

Detalles Bibliográficos
Autores principales: McCusker, Catherine D., Gardiner, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036467/
https://www.ncbi.nlm.nih.gov/pubmed/24872456
http://dx.doi.org/10.1242/dmm.013359
_version_ 1782318159385067520
author McCusker, Catherine D.
Gardiner, David M.
author_facet McCusker, Catherine D.
Gardiner, David M.
author_sort McCusker, Catherine D.
collection PubMed
description Regenerative medicine has reached the point where we are performing clinical trials with stem-cell-derived cell populations in an effort to treat numerous human pathologies. However, many of these efforts have been challenged by the inability of the engrafted populations to properly integrate into the host environment to make a functional biological unit. It is apparent that we must understand the basic biology of tissue integration in order to apply these principles to the development of regenerative therapies in humans. Studying tissue integration in model organisms, where the process of integration between the newly regenerated tissues and the ‘old’ existing structures can be observed and manipulated, can provide valuable insights. Embryonic and adult cells have a memory of their original position, and this positional information can modify surrounding tissues and drive the formation of new structures. In this Review, we discuss the positional interactions that control the ability of grafted cells to integrate into existing tissues during the process of salamander limb regeneration, and discuss how these insights could explain the integration defects observed in current cell-based regenerative therapies. Additionally, we describe potential molecular tools that can be used to manipulate the positional information in grafted cell populations, and to promote the communication of positional cues in the host environment to facilitate the integration of engrafted cells. Lastly, we explain how studying positional information in current cell-based therapies and in regenerating limbs could provide key insights to improve the integration of cell-based regenerative therapies in the future.
format Online
Article
Text
id pubmed-4036467
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Company of Biologists Limited
record_format MEDLINE/PubMed
spelling pubmed-40364672014-07-03 Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies McCusker, Catherine D. Gardiner, David M. Dis Model Mech Review Regenerative medicine has reached the point where we are performing clinical trials with stem-cell-derived cell populations in an effort to treat numerous human pathologies. However, many of these efforts have been challenged by the inability of the engrafted populations to properly integrate into the host environment to make a functional biological unit. It is apparent that we must understand the basic biology of tissue integration in order to apply these principles to the development of regenerative therapies in humans. Studying tissue integration in model organisms, where the process of integration between the newly regenerated tissues and the ‘old’ existing structures can be observed and manipulated, can provide valuable insights. Embryonic and adult cells have a memory of their original position, and this positional information can modify surrounding tissues and drive the formation of new structures. In this Review, we discuss the positional interactions that control the ability of grafted cells to integrate into existing tissues during the process of salamander limb regeneration, and discuss how these insights could explain the integration defects observed in current cell-based regenerative therapies. Additionally, we describe potential molecular tools that can be used to manipulate the positional information in grafted cell populations, and to promote the communication of positional cues in the host environment to facilitate the integration of engrafted cells. Lastly, we explain how studying positional information in current cell-based therapies and in regenerating limbs could provide key insights to improve the integration of cell-based regenerative therapies in the future. The Company of Biologists Limited 2014-06 /pmc/articles/PMC4036467/ /pubmed/24872456 http://dx.doi.org/10.1242/dmm.013359 Text en © 2014. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
McCusker, Catherine D.
Gardiner, David M.
Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title_full Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title_fullStr Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title_full_unstemmed Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title_short Understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
title_sort understanding positional cues in salamander limb regeneration: implications for optimizing cell-based regenerative therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036467/
https://www.ncbi.nlm.nih.gov/pubmed/24872456
http://dx.doi.org/10.1242/dmm.013359
work_keys_str_mv AT mccuskercatherined understandingpositionalcuesinsalamanderlimbregenerationimplicationsforoptimizingcellbasedregenerativetherapies
AT gardinerdavidm understandingpositionalcuesinsalamanderlimbregenerationimplicationsforoptimizingcellbasedregenerativetherapies