Cargando…

Phenotypic rescue of a Drosophila model of mitochondrial ANT1 disease

A point mutation in the Drosophila gene that codes for the major adult isoform of adenine nuclear translocase (ANT) represents a model for human diseases that are associated with ANT insufficiency [stress-sensitive B(1) (sesB(1))]. We characterized the organismal, bioenergetic and molecular phenotyp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vartiainen, Suvi, Chen, Shanjun, George, Jack, Tuomela, Tea, Luoto, Kaisa R., O’Dell, Kevin M. C., Jacobs, Howard T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036471/ https://www.ncbi.nlm.nih.gov/pubmed/24812436 http://dx.doi.org/10.1242/dmm.016527

Ejemplares similares

Nuclear genetic background influences the phenotype of the Drosophila tko(25t) mitochondrial protein-synthesis mutant
por: Jacobs, Howard T, et al.
Publicado: (2023)

Gene Expression in a Drosophila Model of Mitochondrial Disease
por: Fernández-Ayala, Daniel J. M., et al.
Publicado: (2010)

Mitochondrial dysfunction generates a growth-restraining signal linked to pyruvate in Drosophila larvae
por: George, Jack, et al.
Publicado: (2019)

Alternative oxidase confers nutritional limitation on Drosophila development
por: Saari, Sina, et al.
Publicado: (2019)

Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth
por: Kemppainen, Esko, et al.
Publicado: (2016)

Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency
por: Kemppainen, Kia K., et al.
Publicado: (2014)

Correction: Mitochondrial Dysfunction Plus High-Sugar Diet Provokes a Metabolic Crisis That Inhibits Growth
por: Kemppainen, Esko, et al.
Publicado: (2016)

Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells
por: Toompuu, Marina, et al.
Publicado: (2018)

Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism
por: Jacobs, Howard T, et al.
Publicado: (2020)

β carbonic anhydrase is required for female fertility in Drosophila melanogaster
por: Syrjänen, Leo, et al.
Publicado: (2015)

Minimal effects of spargel (PGC-1) overexpression in a Drosophila mitochondrial disease model
por: George, Jack, et al.
Publicado: (2019)

A Cytoplasmic Suppressor of a Nuclear Mutation Affecting Mitochondrial Functions in Drosophila
por: Chen, Shanjun, et al.
Publicado: (2012)

Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase
por: Rodrigues, Ana Paula C., et al.
Publicado: (2018)

Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila
por: Chua, Ling Ling, et al.
Publicado: (2020)

The Alternative Oxidase AOX Does Not Rescue the Phenotype of tko(25t) Mutant Flies
por: Kemppainen, Kia K., et al.
Publicado: (2014)

Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
por: Klein, Pontus, et al.
Publicado: (2014)

RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA
por: González de Cózar, Jose M., et al.
Publicado: (2019)

Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster
por: Salminen, Tiina S., et al.
Publicado: (2019)

Increase in brain glycogen levels ameliorates Huntington's disease phenotype and rescues neurodegeneration in Drosophila
por: Onkar, Akanksha, et al.
Publicado: (2023)

Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
por: Ciesielski, Grzegorz L, et al.
Publicado: (2018)

Mitochondrial ROS production correlates with, but does not directly regulate lifespan in drosophila
por: Sanz, Alberto, et al.
Publicado: (2010)

Saving the injured: Rescue behavior in the termite-hunting ant Megaponera analis
por: Frank, Erik Thomas, et al.
Publicado: (2017)

Comparative analysis of experimental testing procedures for the elicitation of rescue actions in ants
por: Turza, Filip, et al.
Publicado: (2021)

Analysis of Replication Intermediates Indicates That Drosophila melanogaster Mitochondrial DNA Replicates by a Strand-Coupled Theta Mechanism
por: Jõers, Priit, et al.
Publicado: (2013)

The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila
por: M’Angale, P. Githure, et al.
Publicado: (2016)

DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes
por: Zhu, Bangfu, et al.
Publicado: (2022)

A Drosophila Mitochondrial Complex I Deficiency Phenotype Array
por: Foriel, Sarah, et al.
Publicado: (2019)

Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin
por: Dell’Anna, Maria Lucia, et al.
Publicado: (2017)

Secretions of mandibular glands are not involved in the elicitation of rescue behaviour in Formica cinerea ants
por: Miler, K., et al.
Publicado: (2017)

Autophagy inhibition rescues structural and functional defects caused by the loss of mitochondrial chaperone Hsc70-5 in Drosophila
por: Zhu, Jun-yi, et al.
Publicado: (2021)

Phenotypic plasticity in size of ant-domatia
por: Kokolo, Bertrand, et al.
Publicado: (2020)

In Vivo RNAi Rescue in Drosophila melanogaster with Genomic Transgenes from Drosophila pseudoobscura
por: Langer, Christoph C. H., et al.
Publicado: (2010)

Inter-Species Rescue of Mutant Phenotype—The Standard for Genetic Analysis of Human Genetic Disorders in Drosophila melanogaster Model
por: Ecovoiu, Alexandru Al., et al.
Publicado: (2022)

Overexpression of parkin rescues the defective mitochondrial phenotype and the increased apoptosis of Cockayne Syndrome A cells
por: Pascucci, Barbara, et al.
Publicado: (2016)

Ants, Cataglyphis cursor, Use Precisely Directed Rescue Behavior to Free Entrapped Relatives
por: Nowbahari, Elise, et al.
Publicado: (2009)

“O Sister, Where Art Thou?”—A Review on Rescue of Imperiled Individuals in Ants
por: Miler, Krzysztof, et al.
Publicado: (2021)

Stimulating the sir2–spargel axis rescues exercise capacity and mitochondrial respiration in a Drosophila model of Barth syndrome
por: Damschroder, Deena, et al.
Publicado: (2022)

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones
por: Kasture, Ameya, et al.
Publicado: (2016)

Curcumin Effectively Rescued Parkinson's Disease-Like Phenotypes in a Novel Drosophila melanogaster Model with dUCH Knockdown
por: Nguyen, Thi Thanh, et al.
Publicado: (2018)

Defined d-hexapeptides bind CUG repeats and rescue phenotypes of myotonic dystrophy myotubes in a Drosophila model of the disease
por: Rapisarda, Anna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vjnkebi3mderfpf3bo29f3csbb