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Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution
BACKGROUND: Cytochrome P450 CYP2C19 metabolizes a wide range of pharmacologically active substances and a relatively small number of naturally occurring environmental toxins. Poor activity alleles of CYP2C19 are very frequent worldwide, particularly in Asia, raising the possibility that reduced meta...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036532/ https://www.ncbi.nlm.nih.gov/pubmed/24690327 http://dx.doi.org/10.1186/1471-2148-14-71 |