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Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), usin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036547/ https://www.ncbi.nlm.nih.gov/pubmed/24811320 http://dx.doi.org/10.3390/v6052038 |
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author | Restrepo-Gualteros, Sonia M. Jaramillo-Barberi, Lina E. Gonzalez-Santos, Monica Rodriguez-Martinez, Carlos E. Perez, Geovanny F. Gutierrez, Maria J. Nino, Gustavo |
author_facet | Restrepo-Gualteros, Sonia M. Jaramillo-Barberi, Lina E. Gonzalez-Santos, Monica Rodriguez-Martinez, Carlos E. Perez, Geovanny F. Gutierrez, Maria J. Nino, Gustavo |
author_sort | Restrepo-Gualteros, Sonia M. |
collection | PubMed |
description | Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes. |
format | Online Article Text |
id | pubmed-4036547 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40365472014-05-28 Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children Restrepo-Gualteros, Sonia M. Jaramillo-Barberi, Lina E. Gonzalez-Santos, Monica Rodriguez-Martinez, Carlos E. Perez, Geovanny F. Gutierrez, Maria J. Nino, Gustavo Viruses Article Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes. MDPI 2014-05-07 /pmc/articles/PMC4036547/ /pubmed/24811320 http://dx.doi.org/10.3390/v6052038 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Restrepo-Gualteros, Sonia M. Jaramillo-Barberi, Lina E. Gonzalez-Santos, Monica Rodriguez-Martinez, Carlos E. Perez, Geovanny F. Gutierrez, Maria J. Nino, Gustavo Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title | Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title_full | Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title_fullStr | Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title_full_unstemmed | Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title_short | Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children |
title_sort | characterization of cytomegalovirus lung infection in non-hiv infected children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036547/ https://www.ncbi.nlm.nih.gov/pubmed/24811320 http://dx.doi.org/10.3390/v6052038 |
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