Cargando…

Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children

Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), usin...

Descripción completa

Detalles Bibliográficos
Autores principales: Restrepo-Gualteros, Sonia M., Jaramillo-Barberi, Lina E., Gonzalez-Santos, Monica, Rodriguez-Martinez, Carlos E., Perez, Geovanny F., Gutierrez, Maria J., Nino, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036547/
https://www.ncbi.nlm.nih.gov/pubmed/24811320
http://dx.doi.org/10.3390/v6052038
_version_ 1782318173370974208
author Restrepo-Gualteros, Sonia M.
Jaramillo-Barberi, Lina E.
Gonzalez-Santos, Monica
Rodriguez-Martinez, Carlos E.
Perez, Geovanny F.
Gutierrez, Maria J.
Nino, Gustavo
author_facet Restrepo-Gualteros, Sonia M.
Jaramillo-Barberi, Lina E.
Gonzalez-Santos, Monica
Rodriguez-Martinez, Carlos E.
Perez, Geovanny F.
Gutierrez, Maria J.
Nino, Gustavo
author_sort Restrepo-Gualteros, Sonia M.
collection PubMed
description Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes.
format Online
Article
Text
id pubmed-4036547
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40365472014-05-28 Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children Restrepo-Gualteros, Sonia M. Jaramillo-Barberi, Lina E. Gonzalez-Santos, Monica Rodriguez-Martinez, Carlos E. Perez, Geovanny F. Gutierrez, Maria J. Nino, Gustavo Viruses Article Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2–4.9 years), using current molecular and imaging diagnostic modalities, in combination with respiratory signs and symptoms. The most prominent clinical and laboratory findings included cough (100%), hypoxemia (100%), diffuse adventitious breath sounds (100%) and increased respiratory effort (93%). All patients had abnormal lung images characterized by ground glass opacity/consolidation in 80% of cases. CMV was detected in the lung either by CMV PCR in bronchoalveolar lavage (82% detection rate) or histology/immunohistochemistry in lung biopsy (100% detection rate). CMV caused respiratory failure in 47% of children infected and the overall mortality rate was 13.3%. Conclusion: CMV pneumonia is a potential lethal disease in non-HIV infected children that requires a high-index of suspicion. Common clinical and radiological patterns such as hypoxemia, diffuse adventitious lung sounds and ground-glass pulmonary opacities may allow early identification of CMV lung infection in the pediatric population, which may lead to prompt initiation of antiviral therapy and better clinical outcomes. MDPI 2014-05-07 /pmc/articles/PMC4036547/ /pubmed/24811320 http://dx.doi.org/10.3390/v6052038 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Restrepo-Gualteros, Sonia M.
Jaramillo-Barberi, Lina E.
Gonzalez-Santos, Monica
Rodriguez-Martinez, Carlos E.
Perez, Geovanny F.
Gutierrez, Maria J.
Nino, Gustavo
Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title_full Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title_fullStr Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title_full_unstemmed Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title_short Characterization of Cytomegalovirus Lung Infection in Non-HIV Infected Children
title_sort characterization of cytomegalovirus lung infection in non-hiv infected children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036547/
https://www.ncbi.nlm.nih.gov/pubmed/24811320
http://dx.doi.org/10.3390/v6052038
work_keys_str_mv AT restrepogualterossoniam characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT jaramillobarberilinae characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT gonzalezsantosmonica characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT rodriguezmartinezcarlose characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT perezgeovannyf characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT gutierrezmariaj characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren
AT ninogustavo characterizationofcytomegaloviruslunginfectioninnonhivinfectedchildren