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Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis

Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP...

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Autores principales: Zhang, Xin, Meng, Huanxin, Xu, Li, Zhang, Li, Shi, Dong, Feng, Xianghui, Lu, Ruifang, Chen, Zhibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036603/
https://www.ncbi.nlm.nih.gov/pubmed/24899892
http://dx.doi.org/10.1155/2014/783575
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author Zhang, Xin
Meng, Huanxin
Xu, Li
Zhang, Li
Shi, Dong
Feng, Xianghui
Lu, Ruifang
Chen, Zhibin
author_facet Zhang, Xin
Meng, Huanxin
Xu, Li
Zhang, Li
Shi, Dong
Feng, Xianghui
Lu, Ruifang
Chen, Zhibin
author_sort Zhang, Xin
collection PubMed
description Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP), in comparison to healthy controls, with the goal of elucidating the relationship between DBP and GAgP. Fifty-nine GAgP patients and 58 healthy controls were recruited for the study; clinical parameters of probing depths (PD), bleeding index, and attachment loss (AL) were recorded. DBP levels were measured by enzyme-linked immunosorbent assay. From the results, GAgP patients had higher plasma DBP concentrations (P < 0.001) but lower GCF DBP concentrations (P < 0.001) than healthy controls. In GAgP group, after controlling the potential confounders of age, gender, smoking status, and BMI index, GCF DBP concentrations correlated negatively with PD (P < 0.001) and AL (P = 0.009). Within the limits of the study, we concluded that decreased GCF DBP level and increased plasma DBP level are associated with periodontitis.
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spelling pubmed-40366032014-06-04 Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis Zhang, Xin Meng, Huanxin Xu, Li Zhang, Li Shi, Dong Feng, Xianghui Lu, Ruifang Chen, Zhibin Int J Endocrinol Research Article Vitamin D-binding protein (DBP) is the main transport protein of vitamin D and plays an important role in the immune system and host defenses. The purpose of this study was to measure DBP levels in plasma and gingival crevicular fluid (GCF) of patients with generalized aggressive periodontitis (GAgP), in comparison to healthy controls, with the goal of elucidating the relationship between DBP and GAgP. Fifty-nine GAgP patients and 58 healthy controls were recruited for the study; clinical parameters of probing depths (PD), bleeding index, and attachment loss (AL) were recorded. DBP levels were measured by enzyme-linked immunosorbent assay. From the results, GAgP patients had higher plasma DBP concentrations (P < 0.001) but lower GCF DBP concentrations (P < 0.001) than healthy controls. In GAgP group, after controlling the potential confounders of age, gender, smoking status, and BMI index, GCF DBP concentrations correlated negatively with PD (P < 0.001) and AL (P = 0.009). Within the limits of the study, we concluded that decreased GCF DBP level and increased plasma DBP level are associated with periodontitis. Hindawi Publishing Corporation 2014 2014-05-12 /pmc/articles/PMC4036603/ /pubmed/24899892 http://dx.doi.org/10.1155/2014/783575 Text en Copyright © 2014 Xin Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Xin
Meng, Huanxin
Xu, Li
Zhang, Li
Shi, Dong
Feng, Xianghui
Lu, Ruifang
Chen, Zhibin
Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title_full Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title_fullStr Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title_full_unstemmed Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title_short Vitamin D-Binding Protein Levels in Plasma and Gingival Crevicular Fluid of Patients with Generalized Aggressive Periodontitis
title_sort vitamin d-binding protein levels in plasma and gingival crevicular fluid of patients with generalized aggressive periodontitis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036603/
https://www.ncbi.nlm.nih.gov/pubmed/24899892
http://dx.doi.org/10.1155/2014/783575
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