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Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development

Epilepsy is a serious neurological disorder that affects around 50 million people worldwide. Almost 30% of epileptic patients suffer from pharmacoresistance, which is associated with social isolation, dependent behaviour, low marriage rates, unemployment, psychological issues and reduced quality of...

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Autor principal: Wahab, Abdul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036655/
https://www.ncbi.nlm.nih.gov/pubmed/27713344
http://dx.doi.org/10.3390/ph3072090
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author Wahab, Abdul
author_facet Wahab, Abdul
author_sort Wahab, Abdul
collection PubMed
description Epilepsy is a serious neurological disorder that affects around 50 million people worldwide. Almost 30% of epileptic patients suffer from pharmacoresistance, which is associated with social isolation, dependent behaviour, low marriage rates, unemployment, psychological issues and reduced quality of life. Currently available antiepileptic drugs have a limited efficacy, and their negative properties limit their use and cause difficulties in patient management. Antiepileptic drugs can provide only symptomatic relief as these drugs suppress seizures but do not have ability to cure epileptogenesis. The long term use of antiepileptic drugs is limited due to their adverse effects, withdrawal symptoms, deleterious interactions with other drugs and economic burden, especially in developing countries. Furthermore, some of the available antiepileptic drugs may even potentiate certain type of seizures. Several in vivo and in vitro animal models have been proposed and many new antiepileptic drugs have been marketed recently, but large numbers of patients are still pharmacoresistant. This review will highlight the difficulties in treatment and management of epilepsy and the limitations of available antiepileptic drugs and animal seizure models.
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spelling pubmed-40366552014-05-28 Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development Wahab, Abdul Pharmaceuticals (Basel) Review Epilepsy is a serious neurological disorder that affects around 50 million people worldwide. Almost 30% of epileptic patients suffer from pharmacoresistance, which is associated with social isolation, dependent behaviour, low marriage rates, unemployment, psychological issues and reduced quality of life. Currently available antiepileptic drugs have a limited efficacy, and their negative properties limit their use and cause difficulties in patient management. Antiepileptic drugs can provide only symptomatic relief as these drugs suppress seizures but do not have ability to cure epileptogenesis. The long term use of antiepileptic drugs is limited due to their adverse effects, withdrawal symptoms, deleterious interactions with other drugs and economic burden, especially in developing countries. Furthermore, some of the available antiepileptic drugs may even potentiate certain type of seizures. Several in vivo and in vitro animal models have been proposed and many new antiepileptic drugs have been marketed recently, but large numbers of patients are still pharmacoresistant. This review will highlight the difficulties in treatment and management of epilepsy and the limitations of available antiepileptic drugs and animal seizure models. MDPI 2010-07-05 /pmc/articles/PMC4036655/ /pubmed/27713344 http://dx.doi.org/10.3390/ph3072090 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Wahab, Abdul
Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title_full Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title_fullStr Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title_full_unstemmed Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title_short Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development
title_sort difficulties in treatment and management of epilepsy and challenges in new drug development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036655/
https://www.ncbi.nlm.nih.gov/pubmed/27713344
http://dx.doi.org/10.3390/ph3072090
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