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Characterization of Aging-Associated Cardiac Diastolic Dysfunction
AIMS: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of lin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037178/ https://www.ncbi.nlm.nih.gov/pubmed/24869961 http://dx.doi.org/10.1371/journal.pone.0097455 |
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author | Chang, Wei-Ting Chen, Jung-San Hung, Yung-Kung Tsai, Wei-Chuan Juang, Jer-Nan Liu, Ping-Yen |
author_facet | Chang, Wei-Ting Chen, Jung-San Hung, Yung-Kung Tsai, Wei-Chuan Juang, Jer-Nan Liu, Ping-Yen |
author_sort | Chang, Wei-Ting |
collection | PubMed |
description | AIMS: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Image: see text] and wedge pressure. METHODS AND RESULTS: We enrolled 919 patients (male: [Image: see text] [Image: see text]). Compared with the younger population of controls (mean age: [Image: see text] years; [Image: see text]; male: [Image: see text] [Image: see text]), the elderly (mean age: [Image: see text]; [Image: see text]; male: [Image: see text] [Image: see text]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all [Image: see text]). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly ([Image: see text]: [Image: see text] vs. [Image: see text]; [Image: see text]) and corresponded to the higher estimated wedge ([Image: see text]) pressure ([Image: see text] vs. [Image: see text]; [Image: see text]) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with [Image: see text] values [Image: see text]. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. CONCLUSION: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure. |
format | Online Article Text |
id | pubmed-4037178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40371782014-06-02 Characterization of Aging-Associated Cardiac Diastolic Dysfunction Chang, Wei-Ting Chen, Jung-San Hung, Yung-Kung Tsai, Wei-Chuan Juang, Jer-Nan Liu, Ping-Yen PLoS One Research Article AIMS: Diastolic dysfunction is common in geriatric heart failure. A reliable parameter to predict myocardium stiffness and relaxation under similar end-diastolic pressure is being developed. We propose a material and mathematical model for calculating myocardium stiffness based on the concept of linear correlation between [Image: see text] and wedge pressure. METHODS AND RESULTS: We enrolled 919 patients (male: [Image: see text] [Image: see text]). Compared with the younger population of controls (mean age: [Image: see text] years; [Image: see text]; male: [Image: see text] [Image: see text]), the elderly (mean age: [Image: see text]; [Image: see text]; male: [Image: see text] [Image: see text]) had a greater prevalence of hypertension, diabetes mellitus, and coronary artery disease (all [Image: see text]). We collected their M-mode and 2-D echocardiographic volumetric parameters, intraventricular filling pressure, and speckle tracking images to establish a mathematical model. The feasibility of this model was validated. The average early diastolic velocity of the mitral annulus assessed using tissue Doppler imaging was significantly attenuated in the elderly ([Image: see text]: [Image: see text] vs. [Image: see text]; [Image: see text]) and corresponded to the higher estimated wedge ([Image: see text]) pressure ([Image: see text] vs. [Image: see text]; [Image: see text]) in that cohort. E (Young's modulus) was calculated to describe the tensile elasticity of the myocardium. With the same intraventricular filling pressure, E was significantly higher in the elderly, especially those with [Image: see text] values [Image: see text]. Compared with diastolic dysfunction parameters, E also presented sentinel characteristics more sensitive for detecting early myocardial relaxation impairment, which indicates stiffer myocardium in aging hearts. CONCLUSION: Our material and geometric mathematical model successfully described the stiffer myocardium in aging hearts with higher intraventricular pressure. Additional studies that compare individual differences, especially in health status, are needed to validate its application for detecting diastolic heart failure. Public Library of Science 2014-05-28 /pmc/articles/PMC4037178/ /pubmed/24869961 http://dx.doi.org/10.1371/journal.pone.0097455 Text en © 2014 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chang, Wei-Ting Chen, Jung-San Hung, Yung-Kung Tsai, Wei-Chuan Juang, Jer-Nan Liu, Ping-Yen Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title | Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title_full | Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title_fullStr | Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title_full_unstemmed | Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title_short | Characterization of Aging-Associated Cardiac Diastolic Dysfunction |
title_sort | characterization of aging-associated cardiac diastolic dysfunction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037178/ https://www.ncbi.nlm.nih.gov/pubmed/24869961 http://dx.doi.org/10.1371/journal.pone.0097455 |
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