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Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands

OBJECTIVE: To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP), smooth muscle actin (SMA) and CD 43 in pleomorphic adenoma (PA), adenoid cystic carcinoma (AdCC) and polymorphous low grade adenocarcinoma (PLGA) of minor salivary glands. MATERIALS AND METHODS: Tw...

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Autores principales: Zaib, Nadia, Mushtaq, Sajid, Mamoon, Nadira, Akhter, Noreen, Ayaz, Bushra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037265/
https://www.ncbi.nlm.nih.gov/pubmed/24910675
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author Zaib, Nadia
Mushtaq, Sajid
Mamoon, Nadira
Akhter, Noreen
Ayaz, Bushra
author_facet Zaib, Nadia
Mushtaq, Sajid
Mamoon, Nadira
Akhter, Noreen
Ayaz, Bushra
author_sort Zaib, Nadia
collection PubMed
description OBJECTIVE: To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP), smooth muscle actin (SMA) and CD 43 in pleomorphic adenoma (PA), adenoid cystic carcinoma (AdCC) and polymorphous low grade adenocarcinoma (PLGA) of minor salivary glands. MATERIALS AND METHODS: Twenty cases of PA, 20 cases of AdCC and 10 cases of PLGA were retrieved from record files along with their paraffin blocks at Armed Forces Institute of Pathology, Pakistan. New histological diagnosis was made on freshly prepared H&E sections followed by application and analysis of immunostains. RESULTS: The mean age of the patients was 44 ± 15 (mean SD) (range; 17–86) years. There were 26 male and 24 female patients with a male to female ratio of 1.08:1. Fourteen cases of PA, 14 cases of AdCC and 6 cases of PLGA were positive for CD117. In case of GFAP, only 9 cases of AdCC and 3 cases of PLGA were positive; however, 16 cases of PA were also positive. Twelve cases of AdCC and 7 cases of PA were positive for SMA and half of the PLGA cases were also reactive. Nonetheless, the least expression was seen in case of CD 43, where only five cases of AdCC were positive. Six cases of PA and three cases of PLGA were also positive. CONCLUSION: Our results suggest that the use of GFAP, SMA, CD 117 and CD 43 as an adjunct to histological examination is not helpful in differentiating PA, AdCC and PLGA from one another.
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spelling pubmed-40372652014-06-06 Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands Zaib, Nadia Mushtaq, Sajid Mamoon, Nadira Akhter, Noreen Ayaz, Bushra J Dent (Tehran) Original Article OBJECTIVE: To study the immunohistochemical pattern of CD 117, glial fibrillary acidic protein (GFAP), smooth muscle actin (SMA) and CD 43 in pleomorphic adenoma (PA), adenoid cystic carcinoma (AdCC) and polymorphous low grade adenocarcinoma (PLGA) of minor salivary glands. MATERIALS AND METHODS: Twenty cases of PA, 20 cases of AdCC and 10 cases of PLGA were retrieved from record files along with their paraffin blocks at Armed Forces Institute of Pathology, Pakistan. New histological diagnosis was made on freshly prepared H&E sections followed by application and analysis of immunostains. RESULTS: The mean age of the patients was 44 ± 15 (mean SD) (range; 17–86) years. There were 26 male and 24 female patients with a male to female ratio of 1.08:1. Fourteen cases of PA, 14 cases of AdCC and 6 cases of PLGA were positive for CD117. In case of GFAP, only 9 cases of AdCC and 3 cases of PLGA were positive; however, 16 cases of PA were also positive. Twelve cases of AdCC and 7 cases of PA were positive for SMA and half of the PLGA cases were also reactive. Nonetheless, the least expression was seen in case of CD 43, where only five cases of AdCC were positive. Six cases of PA and three cases of PLGA were also positive. CONCLUSION: Our results suggest that the use of GFAP, SMA, CD 117 and CD 43 as an adjunct to histological examination is not helpful in differentiating PA, AdCC and PLGA from one another. Tehran University of Medical Sciences 2014-01 2014-01-31 /pmc/articles/PMC4037265/ /pubmed/24910675 Text en Copyright © Dental Research Center, Tehran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Zaib, Nadia
Mushtaq, Sajid
Mamoon, Nadira
Akhter, Noreen
Ayaz, Bushra
Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title_full Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title_fullStr Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title_full_unstemmed Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title_short Immunohistochemical Pattern of Pleomorphic Adenoma, Polymorphous Low Grade Adenocarcinoma and Adenoid Cystic Carcinoma in Minor Salivary Glands
title_sort immunohistochemical pattern of pleomorphic adenoma, polymorphous low grade adenocarcinoma and adenoid cystic carcinoma in minor salivary glands
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037265/
https://www.ncbi.nlm.nih.gov/pubmed/24910675
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