Cargando…
Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models
Crocus sativus L. extracts (saffron) are rich in carotenoids. Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles. We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activit...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037572/ https://www.ncbi.nlm.nih.gov/pubmed/24900952 http://dx.doi.org/10.1155/2014/135048 |
_version_ | 1782318251360911360 |
---|---|
author | Festuccia, Claudio Mancini, Andrea Gravina, Giovanni Luca Scarsella, Luca Llorens, Silvia Alonso, Gonzalo L. Tatone, Carla Di Cesare, Ernesto Jannini, Emmanuele A. Lenzi, Andrea D'Alessandro, Anna M. Carmona, Manuel |
author_facet | Festuccia, Claudio Mancini, Andrea Gravina, Giovanni Luca Scarsella, Luca Llorens, Silvia Alonso, Gonzalo L. Tatone, Carla Di Cesare, Ernesto Jannini, Emmanuele A. Lenzi, Andrea D'Alessandro, Anna M. Carmona, Manuel |
author_sort | Festuccia, Claudio |
collection | PubMed |
description | Crocus sativus L. extracts (saffron) are rich in carotenoids. Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles. We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest in prostate cancer (PCa) cells. It has also been demonstrated that crocetin esters are produced after SE gastrointestinal digestion by CR hydrolysis. The aim of the present report was to investigate if SE, crocetin (CCT), and CR affected in vivo tumor growth of two aggressive PCa cell lines (PC3 and 22rv1) which were xenografted in male nude mice treated by oral gavage with SE, CR, and CCT. We demonstrated that the antitumor effects of CCT were higher when compared to CR and SE and treatments reverted the epithelial-mesenchymal transdifferentiation (EMT) as attested by the significant reduction of N-cadherin and beta-catenin expression and the increased expression of E-cadherin. Additionally, SE, CR, and CCT inhibited PCa cell invasion and migration through the downmodulation of metalloproteinase and urokinase expression/activity suggesting that these agents may affect metastatic processes. Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells. |
format | Online Article Text |
id | pubmed-4037572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40375722014-06-04 Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models Festuccia, Claudio Mancini, Andrea Gravina, Giovanni Luca Scarsella, Luca Llorens, Silvia Alonso, Gonzalo L. Tatone, Carla Di Cesare, Ernesto Jannini, Emmanuele A. Lenzi, Andrea D'Alessandro, Anna M. Carmona, Manuel Biomed Res Int Research Article Crocus sativus L. extracts (saffron) are rich in carotenoids. Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles. We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest in prostate cancer (PCa) cells. It has also been demonstrated that crocetin esters are produced after SE gastrointestinal digestion by CR hydrolysis. The aim of the present report was to investigate if SE, crocetin (CCT), and CR affected in vivo tumor growth of two aggressive PCa cell lines (PC3 and 22rv1) which were xenografted in male nude mice treated by oral gavage with SE, CR, and CCT. We demonstrated that the antitumor effects of CCT were higher when compared to CR and SE and treatments reverted the epithelial-mesenchymal transdifferentiation (EMT) as attested by the significant reduction of N-cadherin and beta-catenin expression and the increased expression of E-cadherin. Additionally, SE, CR, and CCT inhibited PCa cell invasion and migration through the downmodulation of metalloproteinase and urokinase expression/activity suggesting that these agents may affect metastatic processes. Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells. Hindawi Publishing Corporation 2014 2014-05-11 /pmc/articles/PMC4037572/ /pubmed/24900952 http://dx.doi.org/10.1155/2014/135048 Text en Copyright © 2014 Claudio Festuccia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Festuccia, Claudio Mancini, Andrea Gravina, Giovanni Luca Scarsella, Luca Llorens, Silvia Alonso, Gonzalo L. Tatone, Carla Di Cesare, Ernesto Jannini, Emmanuele A. Lenzi, Andrea D'Alessandro, Anna M. Carmona, Manuel Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title | Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title_full | Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title_fullStr | Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title_full_unstemmed | Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title_short | Antitumor Effects of Saffron-Derived Carotenoids in Prostate Cancer Cell Models |
title_sort | antitumor effects of saffron-derived carotenoids in prostate cancer cell models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037572/ https://www.ncbi.nlm.nih.gov/pubmed/24900952 http://dx.doi.org/10.1155/2014/135048 |
work_keys_str_mv | AT festucciaclaudio antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT manciniandrea antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT gravinagiovanniluca antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT scarsellaluca antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT llorenssilvia antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT alonsogonzalol antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT tatonecarla antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT dicesareernesto antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT janniniemmanuelea antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT lenziandrea antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT dalessandroannam antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels AT carmonamanuel antitumoreffectsofsaffronderivedcarotenoidsinprostatecancercellmodels |