Cargando…

Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis

Background. Acetone, β-hydroxybutyric acid, and acetoacetic acid are three types of ketone body that may be found in the breath, blood, and urine. Detecting altered concentrations of ketones in the breath, blood, and urine is crucial for the diagnosis and treatment of diabetic ketosis. The aim of th...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiao, Yue, Gao, Zhaohua, Liu, Yong, Cheng, Yan, Yu, Mengxiao, Zhao, Lingling, Duan, Yixiang, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037575/
https://www.ncbi.nlm.nih.gov/pubmed/24900994
http://dx.doi.org/10.1155/2014/869186
_version_ 1782318252055068672
author Qiao, Yue
Gao, Zhaohua
Liu, Yong
Cheng, Yan
Yu, Mengxiao
Zhao, Lingling
Duan, Yixiang
Liu, Yu
author_facet Qiao, Yue
Gao, Zhaohua
Liu, Yong
Cheng, Yan
Yu, Mengxiao
Zhao, Lingling
Duan, Yixiang
Liu, Yu
author_sort Qiao, Yue
collection PubMed
description Background. Acetone, β-hydroxybutyric acid, and acetoacetic acid are three types of ketone body that may be found in the breath, blood, and urine. Detecting altered concentrations of ketones in the breath, blood, and urine is crucial for the diagnosis and treatment of diabetic ketosis. The aim of this study was to evaluate the advantages of different detection methods for ketones, and to establish whether detection of the concentration of ketones in the breath is an effective and practical technique. Methods. We measured the concentrations of acetone in the breath using gas chromatography-mass spectrometry and β-hydroxybutyrate in fingertip blood collected from 99 patients with diabetes assigned to groups 1 (−), 2 (±), 3 (+), 4 (++), or 5 (+++) according to urinary ketone concentrations. Results. There were strong relationships between fasting blood glucose, age, and diabetic ketosis. Exhaled acetone concentration significantly correlated with concentrations of fasting blood glucose, ketones in the blood and urine, LDL-C, creatinine, and blood urea nitrogen. Conclusions. Breath testing for ketones has a high sensitivity and specificity and appears to be a noninvasive, convenient, and repeatable method for the diagnosis and therapeutic monitoring of diabetic ketosis.
format Online
Article
Text
id pubmed-4037575
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40375752014-06-04 Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis Qiao, Yue Gao, Zhaohua Liu, Yong Cheng, Yan Yu, Mengxiao Zhao, Lingling Duan, Yixiang Liu, Yu Biomed Res Int Research Article Background. Acetone, β-hydroxybutyric acid, and acetoacetic acid are three types of ketone body that may be found in the breath, blood, and urine. Detecting altered concentrations of ketones in the breath, blood, and urine is crucial for the diagnosis and treatment of diabetic ketosis. The aim of this study was to evaluate the advantages of different detection methods for ketones, and to establish whether detection of the concentration of ketones in the breath is an effective and practical technique. Methods. We measured the concentrations of acetone in the breath using gas chromatography-mass spectrometry and β-hydroxybutyrate in fingertip blood collected from 99 patients with diabetes assigned to groups 1 (−), 2 (±), 3 (+), 4 (++), or 5 (+++) according to urinary ketone concentrations. Results. There were strong relationships between fasting blood glucose, age, and diabetic ketosis. Exhaled acetone concentration significantly correlated with concentrations of fasting blood glucose, ketones in the blood and urine, LDL-C, creatinine, and blood urea nitrogen. Conclusions. Breath testing for ketones has a high sensitivity and specificity and appears to be a noninvasive, convenient, and repeatable method for the diagnosis and therapeutic monitoring of diabetic ketosis. Hindawi Publishing Corporation 2014 2014-05-11 /pmc/articles/PMC4037575/ /pubmed/24900994 http://dx.doi.org/10.1155/2014/869186 Text en Copyright © 2014 Yue Qiao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qiao, Yue
Gao, Zhaohua
Liu, Yong
Cheng, Yan
Yu, Mengxiao
Zhao, Lingling
Duan, Yixiang
Liu, Yu
Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title_full Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title_fullStr Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title_full_unstemmed Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title_short Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis
title_sort breath ketone testing: a new biomarker for diagnosis and therapeutic monitoring of diabetic ketosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037575/
https://www.ncbi.nlm.nih.gov/pubmed/24900994
http://dx.doi.org/10.1155/2014/869186
work_keys_str_mv AT qiaoyue breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT gaozhaohua breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT liuyong breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT chengyan breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT yumengxiao breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT zhaolingling breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT duanyixiang breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis
AT liuyu breathketonetestinganewbiomarkerfordiagnosisandtherapeuticmonitoringofdiabeticketosis