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New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction
Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have show...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037580/ https://www.ncbi.nlm.nih.gov/pubmed/24900995 http://dx.doi.org/10.1155/2014/872984 |
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author | Liao, Yang-Ying Chen, Zhi-Yi Wang, Yi-Xiang Lin, Yan Yang, Feng Zhou, Qiu-Lan |
author_facet | Liao, Yang-Ying Chen, Zhi-Yi Wang, Yi-Xiang Lin, Yan Yang, Feng Zhou, Qiu-Lan |
author_sort | Liao, Yang-Ying |
collection | PubMed |
description | Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches. |
format | Online Article Text |
id | pubmed-4037580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40375802014-06-04 New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction Liao, Yang-Ying Chen, Zhi-Yi Wang, Yi-Xiang Lin, Yan Yang, Feng Zhou, Qiu-Lan Biomed Res Int Review Article Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches. Hindawi Publishing Corporation 2014 2014-05-12 /pmc/articles/PMC4037580/ /pubmed/24900995 http://dx.doi.org/10.1155/2014/872984 Text en Copyright © 2014 Yang-Ying Liao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Liao, Yang-Ying Chen, Zhi-Yi Wang, Yi-Xiang Lin, Yan Yang, Feng Zhou, Qiu-Lan New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title | New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_full | New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_fullStr | New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_full_unstemmed | New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_short | New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction |
title_sort | new progress in angiogenesis therapy of cardiovascular disease by ultrasound targeted microbubble destruction |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037580/ https://www.ncbi.nlm.nih.gov/pubmed/24900995 http://dx.doi.org/10.1155/2014/872984 |
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