Genetics and genomics of alcohol sensitivity

Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivit...

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Detalles Bibliográficos
Autores principales: Morozova, Tatiana V., Mackay, Trudy F. C., Anholt, Robert R. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037586/
https://www.ncbi.nlm.nih.gov/pubmed/24395673
http://dx.doi.org/10.1007/s00438-013-0808-y
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author Morozova, Tatiana V.
Mackay, Trudy F. C.
Anholt, Robert R. H.
author_facet Morozova, Tatiana V.
Mackay, Trudy F. C.
Anholt, Robert R. H.
author_sort Morozova, Tatiana V.
collection PubMed
description Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well as human populations that represent our current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00438-013-0808-y) contains supplementary material, which is available to authorized users.
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spelling pubmed-40375862014-05-29 Genetics and genomics of alcohol sensitivity Morozova, Tatiana V. Mackay, Trudy F. C. Anholt, Robert R. H. Mol Genet Genomics Review Alcohol abuse and alcoholism incur a heavy socioeconomic cost in many countries. Both genetic and environmental factors contribute to variation in the inebriating effects of alcohol and alcohol addiction among individuals within and across populations. From a genetics perspective, alcohol sensitivity is a quantitative trait determined by the cumulative effects of multiple segregating genes and their interactions with the environment. This review summarizes insights from model organisms as well as human populations that represent our current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00438-013-0808-y) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2014-01-07 2014 /pmc/articles/PMC4037586/ /pubmed/24395673 http://dx.doi.org/10.1007/s00438-013-0808-y Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Morozova, Tatiana V.
Mackay, Trudy F. C.
Anholt, Robert R. H.
Genetics and genomics of alcohol sensitivity
title Genetics and genomics of alcohol sensitivity
title_full Genetics and genomics of alcohol sensitivity
title_fullStr Genetics and genomics of alcohol sensitivity
title_full_unstemmed Genetics and genomics of alcohol sensitivity
title_short Genetics and genomics of alcohol sensitivity
title_sort genetics and genomics of alcohol sensitivity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037586/
https://www.ncbi.nlm.nih.gov/pubmed/24395673
http://dx.doi.org/10.1007/s00438-013-0808-y
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