Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies

BACKGROUND AND OBJECTIVES: Fexinidazole is a 5-nitroimidazole recently included in a clinical efficacy trial as an oral drug for the treatment of human African trypanosomiasis (HAT). Preclinical studies showed it acts as a pharmacologically active pro-drug with two key active metabolites: sulfoxide...

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Detalles Bibliográficos
Autores principales: Tarral, Antoine, Blesson, Séverine, Mordt, Olaf Valverde, Torreele, Els, Sassella, Daniela, Bray, Michael A., Hovsepian, Lionel, Evène, Eric, Gualano, Virginie, Felices, Mathieu, Strub-Wourgaft, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037587/
https://www.ncbi.nlm.nih.gov/pubmed/24535888
http://dx.doi.org/10.1007/s40262-014-0136-3

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