Cargando…
Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65)
The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65). Thirty-six mice were divided into six groups of six mice each. Five groups (B...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037601/ https://www.ncbi.nlm.nih.gov/pubmed/24900913 http://dx.doi.org/10.1155/2014/731906 |
_version_ | 1782318257960648704 |
---|---|
author | Gboeloh, Lebari Barine Okon, Okpok Eta Udoh, Samuel Effiong |
author_facet | Gboeloh, Lebari Barine Okon, Okpok Eta Udoh, Samuel Effiong |
author_sort | Gboeloh, Lebari Barine |
collection | PubMed |
description | The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65). Thirty-six mice were divided into six groups of six mice each. Five groups (B(1)–B(3), D, and G) were infected with Plasmodium berghei berghei parasitized red blood cells. Groups D, H, and G served as the controls. Six days after infection, mice in groups B(1), B(2), and B(3) were treated orally with 100, 200, and 400 mg/kg body weight of Anthocleista vogelii, respectively, for six executive days. Group D was treated with 5 mg/kg body weight of chloroquine while Group G was given distilled water. Group H was not infected and was not treated. It served as the normal control. The extracts exhibited significant (P < 0.05) dose-dependent chemosuppression of P. berghei. The extract exhibited average chemosuppressive effects of 48.5%, 78.5%, and 86.6% at dose levels of 100, 200, and 400 mg/kg body weight, respectively. Phytochemical screening of the plant extract revealed the presence of saponins, cardiac glycosides, flavonoids, terpenes, alkaloids, and steroid. The acute toxicity (LD(50)) of the plant was estimated to be 3162 mg/kg body weight. It showed that the stem bark of A. vogelii possesses antiplasmodial property. |
format | Online Article Text |
id | pubmed-4037601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40376012014-06-04 Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) Gboeloh, Lebari Barine Okon, Okpok Eta Udoh, Samuel Effiong J Parasitol Res Research Article The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65). Thirty-six mice were divided into six groups of six mice each. Five groups (B(1)–B(3), D, and G) were infected with Plasmodium berghei berghei parasitized red blood cells. Groups D, H, and G served as the controls. Six days after infection, mice in groups B(1), B(2), and B(3) were treated orally with 100, 200, and 400 mg/kg body weight of Anthocleista vogelii, respectively, for six executive days. Group D was treated with 5 mg/kg body weight of chloroquine while Group G was given distilled water. Group H was not infected and was not treated. It served as the normal control. The extracts exhibited significant (P < 0.05) dose-dependent chemosuppression of P. berghei. The extract exhibited average chemosuppressive effects of 48.5%, 78.5%, and 86.6% at dose levels of 100, 200, and 400 mg/kg body weight, respectively. Phytochemical screening of the plant extract revealed the presence of saponins, cardiac glycosides, flavonoids, terpenes, alkaloids, and steroid. The acute toxicity (LD(50)) of the plant was estimated to be 3162 mg/kg body weight. It showed that the stem bark of A. vogelii possesses antiplasmodial property. Hindawi Publishing Corporation 2014 2014-05-11 /pmc/articles/PMC4037601/ /pubmed/24900913 http://dx.doi.org/10.1155/2014/731906 Text en Copyright © 2014 Lebari Barine Gboeloh et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Gboeloh, Lebari Barine Okon, Okpok Eta Udoh, Samuel Effiong Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title | Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title_full | Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title_fullStr | Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title_full_unstemmed | Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title_short | Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65) |
title_sort | antiplasmodial effect of anthocleista vogelii on albino mice experimentally infected with plasmodium berghei berghei (nk 65) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037601/ https://www.ncbi.nlm.nih.gov/pubmed/24900913 http://dx.doi.org/10.1155/2014/731906 |
work_keys_str_mv | AT gboelohlebaribarine antiplasmodialeffectofanthocleistavogeliionalbinomiceexperimentallyinfectedwithplasmodiumbergheibergheink65 AT okonokpoketa antiplasmodialeffectofanthocleistavogeliionalbinomiceexperimentallyinfectedwithplasmodiumbergheibergheink65 AT udohsamueleffiong antiplasmodialeffectofanthocleistavogeliionalbinomiceexperimentallyinfectedwithplasmodiumbergheibergheink65 |