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Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells
A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037711/ https://www.ncbi.nlm.nih.gov/pubmed/24869783 http://dx.doi.org/10.1038/srep05103 |
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author | Chen, Chunhai Ma, Qinlong Liu, Chuan Deng, Ping Zhu, Gang Zhang, Lei He, Mindi Lu, Yonghui Duan, Weixia Pei, Liping Li, Min Yu, Zhengping Zhou, Zhou |
author_facet | Chen, Chunhai Ma, Qinlong Liu, Chuan Deng, Ping Zhu, Gang Zhang, Lei He, Mindi Lu, Yonghui Duan, Weixia Pei, Liping Li, Min Yu, Zhengping Zhou, Zhou |
author_sort | Chen, Chunhai |
collection | PubMed |
description | A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important for exploring the effects of RF-EMF on brain development. Here, we exposed eNSCs to 1800 MHz RF-EMF at specific absorption rate (SAR) values of 1, 2, and 4 W/kg for 1, 2, and 3 days. We found that 1800 MHz RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle or the mRNA expressions of related genes. RF-EMF exposure also did not alter the ratio of eNSC differentiated neurons and astrocytes. However, neurite outgrowth of eNSC differentiated neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. Additionally, the mRNA and protein expression of the proneural genes Ngn1 and NeuroD, which are crucial for neurite outgrowth, were decreased after RF-EMF exposure. The expression of their inhibitor Hes1 was upregulated by RF-EMF exposure. These results together suggested that 1800 MHz RF-EMF exposure impairs neurite outgrowth of eNSCs. More attention should be given to the potential adverse effects of RF-EMF exposure on brain development. |
format | Online Article Text |
id | pubmed-4037711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40377112014-05-30 Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells Chen, Chunhai Ma, Qinlong Liu, Chuan Deng, Ping Zhu, Gang Zhang, Lei He, Mindi Lu, Yonghui Duan, Weixia Pei, Liping Li, Min Yu, Zhengping Zhou, Zhou Sci Rep Article A radiofrequency electromagnetic field (RF-EMF) of 1800 MHz is widely used in mobile communications. However, the effects of RF-EMFs on cell biology are unclear. Embryonic neural stem cells (eNSCs) play a critical role in brain development. Thus, detecting the effects of RF-EMF on eNSCs is important for exploring the effects of RF-EMF on brain development. Here, we exposed eNSCs to 1800 MHz RF-EMF at specific absorption rate (SAR) values of 1, 2, and 4 W/kg for 1, 2, and 3 days. We found that 1800 MHz RF-EMF exposure did not influence eNSC apoptosis, proliferation, cell cycle or the mRNA expressions of related genes. RF-EMF exposure also did not alter the ratio of eNSC differentiated neurons and astrocytes. However, neurite outgrowth of eNSC differentiated neurons was inhibited after 4 W/kg RF-EMF exposure for 3 days. Additionally, the mRNA and protein expression of the proneural genes Ngn1 and NeuroD, which are crucial for neurite outgrowth, were decreased after RF-EMF exposure. The expression of their inhibitor Hes1 was upregulated by RF-EMF exposure. These results together suggested that 1800 MHz RF-EMF exposure impairs neurite outgrowth of eNSCs. More attention should be given to the potential adverse effects of RF-EMF exposure on brain development. Nature Publishing Group 2014-05-29 /pmc/articles/PMC4037711/ /pubmed/24869783 http://dx.doi.org/10.1038/srep05103 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images in this article are included in the article's Creative Commons license, unless indicated otherwise in the image credit; if the image is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the image. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Chen, Chunhai Ma, Qinlong Liu, Chuan Deng, Ping Zhu, Gang Zhang, Lei He, Mindi Lu, Yonghui Duan, Weixia Pei, Liping Li, Min Yu, Zhengping Zhou, Zhou Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title | Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title_full | Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title_fullStr | Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title_full_unstemmed | Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title_short | Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
title_sort | exposure to 1800 mhz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037711/ https://www.ncbi.nlm.nih.gov/pubmed/24869783 http://dx.doi.org/10.1038/srep05103 |
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