Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation

BACKGROUND: Elevated expression of focal adhesion kinase (FAK) occurs in numerous human cancers including colon-, cervix- and breast cancer. Although several studies have implicated FAK in mammary tumour formation induced by ectopic oncogene expression, evidence supporting a role for FAK in spontane...

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Detalles Bibliográficos
Autores principales: van Miltenburg, M H A M, van Nimwegen, M J, Tijdens, I, Lalai, R, Kuiper, R, Klarenbeek, S, Schouten, P C, de Vries, A, Jonkers, J, van de Water, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037829/
https://www.ncbi.nlm.nih.gov/pubmed/24809783
http://dx.doi.org/10.1038/bjc.2014.219

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