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Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases

BACKGROUND: Caveolin-1 is a key structural and functional protein. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal...

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Autores principales: Zhang, Feng, Li, Heyu, Zhou, Yicheng, Gu, Yunhe, Wang, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037939/
https://www.ncbi.nlm.nih.gov/pubmed/24891649
http://dx.doi.org/10.4103/0019-5154.131374
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author Zhang, Feng
Li, Heyu
Zhou, Yicheng
Gu, Yunhe
Wang, Lifeng
author_facet Zhang, Feng
Li, Heyu
Zhou, Yicheng
Gu, Yunhe
Wang, Lifeng
author_sort Zhang, Feng
collection PubMed
description BACKGROUND: Caveolin-1 is a key structural and functional protein. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal cell maturation. OBJECTIVES: To examine the expression of caveolin-1 in skin biopsies from normal subjects, patients, and subjects with the three respective isoforms of psoriasis (psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis). The expression level of caveolin-1 was compared among psoriasis vulgaris, localized pustular psoriasis, erythrodermic psoriasis, and normal subjects. MATERIALS AND METHODS: Using immunohistochemical methods, caveolin-1 protein expression was assayed in four groups. An analysis was conducted on skin samples obtained from 22 normal subjects and 28 patients with psoriasis vulgaris, 22 patients with localized pustular psoriasis, and 16 patients with erythrodermic psoriasis. The statistical analysis of the scoring criteria reflecting the level of Caveolin-1 immunostaining between different groups was determined using the Mann–Whitney U-test. RESULTS: In the normal skin, intense and consistent caveolin-1 staining was present in 22 cases. The Caveolin-1 protein was significantly reduced and showed very weak or absent staining within the tissues of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis (respective P < 0.001). Caveolin-1 protein expression in psoriasis vulgaris was higher than that in localized pustular psoriasis and erythrodermic psoriasis (respective P < 0.05). Caveolin-1 protein expression was no different in localized pustular psoriasis and erythrodermic psoriasis (P > 0.05). CONCLUSION: The finding of this study was consistent with a downregulation of Caveolin-1, which might serve as an etiological factor in the development of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis. Further mechanistic investigations are required to prove that Caveolin-1 protein has the potential and may be a novel target for therapy of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis.
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spelling pubmed-40379392014-06-02 Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases Zhang, Feng Li, Heyu Zhou, Yicheng Gu, Yunhe Wang, Lifeng Indian J Dermatol Basic Research BACKGROUND: Caveolin-1 is a key structural and functional protein. Caveolin-1 is known to modulate multiple signal-transducing pathways involved in cell differentiation and proliferation. Psoriasis is viewed as a multifactorial pathology characterized by keratinocyte hyperproliferation and abnormal cell maturation. OBJECTIVES: To examine the expression of caveolin-1 in skin biopsies from normal subjects, patients, and subjects with the three respective isoforms of psoriasis (psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis). The expression level of caveolin-1 was compared among psoriasis vulgaris, localized pustular psoriasis, erythrodermic psoriasis, and normal subjects. MATERIALS AND METHODS: Using immunohistochemical methods, caveolin-1 protein expression was assayed in four groups. An analysis was conducted on skin samples obtained from 22 normal subjects and 28 patients with psoriasis vulgaris, 22 patients with localized pustular psoriasis, and 16 patients with erythrodermic psoriasis. The statistical analysis of the scoring criteria reflecting the level of Caveolin-1 immunostaining between different groups was determined using the Mann–Whitney U-test. RESULTS: In the normal skin, intense and consistent caveolin-1 staining was present in 22 cases. The Caveolin-1 protein was significantly reduced and showed very weak or absent staining within the tissues of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis (respective P < 0.001). Caveolin-1 protein expression in psoriasis vulgaris was higher than that in localized pustular psoriasis and erythrodermic psoriasis (respective P < 0.05). Caveolin-1 protein expression was no different in localized pustular psoriasis and erythrodermic psoriasis (P > 0.05). CONCLUSION: The finding of this study was consistent with a downregulation of Caveolin-1, which might serve as an etiological factor in the development of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis. Further mechanistic investigations are required to prove that Caveolin-1 protein has the potential and may be a novel target for therapy of psoriasis vulgaris, localized pustular psoriasis, and erythrodermic psoriasis. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4037939/ /pubmed/24891649 http://dx.doi.org/10.4103/0019-5154.131374 Text en Copyright: © Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic Research
Zhang, Feng
Li, Heyu
Zhou, Yicheng
Gu, Yunhe
Wang, Lifeng
Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title_full Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title_fullStr Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title_full_unstemmed Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title_short Caveolin-1 Expression in Different Types of Psoriatic Lesions: Analysis of 66 Cases
title_sort caveolin-1 expression in different types of psoriatic lesions: analysis of 66 cases
topic Basic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037939/
https://www.ncbi.nlm.nih.gov/pubmed/24891649
http://dx.doi.org/10.4103/0019-5154.131374
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