Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measur...

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Detalles Bibliográficos
Autores principales: Hapuarachchi, Tharindi, Moroz, Tracy, Bainbridge, Alan, Price, David, Cady, Ernest, Baer, Esther, Broad, Kevin, Ezzati, Mojgan, Thomas, David, Golay, Xavier, Robertson, Nicola J., Tachtsidis, Ilias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer New York 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037998/
https://www.ncbi.nlm.nih.gov/pubmed/23852512
http://dx.doi.org/10.1007/978-1-4614-7411-1_44
Descripción
Sumario:We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.

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