Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes

We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measur...

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Autores principales: Hapuarachchi, Tharindi, Moroz, Tracy, Bainbridge, Alan, Price, David, Cady, Ernest, Baer, Esther, Broad, Kevin, Ezzati, Mojgan, Thomas, David, Golay, Xavier, Robertson, Nicola J., Tachtsidis, Ilias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer New York 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037998/
https://www.ncbi.nlm.nih.gov/pubmed/23852512
http://dx.doi.org/10.1007/978-1-4614-7411-1_44
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author Hapuarachchi, Tharindi
Moroz, Tracy
Bainbridge, Alan
Price, David
Cady, Ernest
Baer, Esther
Broad, Kevin
Ezzati, Mojgan
Thomas, David
Golay, Xavier
Robertson, Nicola J.
Tachtsidis, Ilias
author_facet Hapuarachchi, Tharindi
Moroz, Tracy
Bainbridge, Alan
Price, David
Cady, Ernest
Baer, Esther
Broad, Kevin
Ezzati, Mojgan
Thomas, David
Golay, Xavier
Robertson, Nicola J.
Tachtsidis, Ilias
author_sort Hapuarachchi, Tharindi
collection PubMed
description We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model.
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spelling pubmed-40379982014-06-02 Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes Hapuarachchi, Tharindi Moroz, Tracy Bainbridge, Alan Price, David Cady, Ernest Baer, Esther Broad, Kevin Ezzati, Mojgan Thomas, David Golay, Xavier Robertson, Nicola J. Tachtsidis, Ilias Adv Exp Med Biol Article We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using (31)P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model. Springer New York 2013-03-25 /pmc/articles/PMC4037998/ /pubmed/23852512 http://dx.doi.org/10.1007/978-1-4614-7411-1_44 Text en © The Author(s) 2013 Open Access This chapter is licensed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.The images or other third party material in this chapter are included in the chapter’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the chapter’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
spellingShingle Article
Hapuarachchi, Tharindi
Moroz, Tracy
Bainbridge, Alan
Price, David
Cady, Ernest
Baer, Esther
Broad, Kevin
Ezzati, Mojgan
Thomas, David
Golay, Xavier
Robertson, Nicola J.
Tachtsidis, Ilias
Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title_full Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title_fullStr Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title_full_unstemmed Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title_short Modelling Blood Flow and Metabolism in the Piglet Brain During Hypoxia-Ischaemia: Simulating pH Changes
title_sort modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: simulating ph changes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037998/
https://www.ncbi.nlm.nih.gov/pubmed/23852512
http://dx.doi.org/10.1007/978-1-4614-7411-1_44
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