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Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre
Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance freq...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038016/ https://www.ncbi.nlm.nih.gov/pubmed/21445764 http://dx.doi.org/10.1007/978-1-4419-7756-4_3 |
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author | Gao, Lei Elwell, Clare E. Kohl-Bareis, Matthias Gramer, Marcus Cooper, Chris E. Leung, Terence S Tachtsidis, Ilias |
author_facet | Gao, Lei Elwell, Clare E. Kohl-Bareis, Matthias Gramer, Marcus Cooper, Chris E. Leung, Terence S Tachtsidis, Ilias |
author_sort | Gao, Lei |
collection | PubMed |
description | Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance frequency and broadband systems to investigate the changes in scattering and pathlength during a Valsalva manoeuvre in 8 adult volunteers. Results show a significant increase in the reduced scattering coefficient of 17% at 790nm and 850nm in 4 volunteers during the peak of the Valsalva. However, these scattering changes do not appear to significantly affect the differential pathlength factor and the tissue haemoglobin concentration measurements. |
format | Online Article Text |
id | pubmed-4038016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-40380162014-06-02 Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre Gao, Lei Elwell, Clare E. Kohl-Bareis, Matthias Gramer, Marcus Cooper, Chris E. Leung, Terence S Tachtsidis, Ilias Adv Exp Med Biol Article Resolving for changes in concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy has generally been based on the assumption that optical scattering and pathlength remain constant. We have used a novel hybrid optical spectrometer that combines multi-distance frequency and broadband systems to investigate the changes in scattering and pathlength during a Valsalva manoeuvre in 8 adult volunteers. Results show a significant increase in the reduced scattering coefficient of 17% at 790nm and 850nm in 4 volunteers during the peak of the Valsalva. However, these scattering changes do not appear to significantly affect the differential pathlength factor and the tissue haemoglobin concentration measurements. Springer 2011 /pmc/articles/PMC4038016/ /pubmed/21445764 http://dx.doi.org/10.1007/978-1-4419-7756-4_3 Text en |
spellingShingle | Article Gao, Lei Elwell, Clare E. Kohl-Bareis, Matthias Gramer, Marcus Cooper, Chris E. Leung, Terence S Tachtsidis, Ilias Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title | Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title_full | Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title_fullStr | Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title_full_unstemmed | Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title_short | Effects of assuming constant optical scattering on haemoglobin concentration measurements using NIRS during a Valsalva Manoeuvre |
title_sort | effects of assuming constant optical scattering on haemoglobin concentration measurements using nirs during a valsalva manoeuvre |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038016/ https://www.ncbi.nlm.nih.gov/pubmed/21445764 http://dx.doi.org/10.1007/978-1-4419-7756-4_3 |
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