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Atomistic Autophagy: The Structures of Cellular Self-Digestion
Autophagy is directed by numerous distinct autophagy-related (Atg) proteins. These transmit starvation-induced signals to lipids and regulatory proteins and assemble a double-membrane autophagosome sequestering bulk cytoplasm and/or selected cargos destined for degradation upon autophagosome fusion...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038036/ https://www.ncbi.nlm.nih.gov/pubmed/24725401 http://dx.doi.org/10.1016/j.cell.2014.01.070 |
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author | Hurley, James H. Schulman, Brenda A. |
author_facet | Hurley, James H. Schulman, Brenda A. |
author_sort | Hurley, James H. |
collection | PubMed |
description | Autophagy is directed by numerous distinct autophagy-related (Atg) proteins. These transmit starvation-induced signals to lipids and regulatory proteins and assemble a double-membrane autophagosome sequestering bulk cytoplasm and/or selected cargos destined for degradation upon autophagosome fusion with a vacuole or lysosome. This Review discusses the structural mechanisms by which Atg proteins sense membrane curvature, mediate a PI(3)P-signaling cascade, and utilize autophagy-specific ubiquitin-like protein cascades to tether proteins to autophagosomal membranes. Recent elucidation of molecular interactions enabling vesicle nucleation, elongation, and cargo recruitment provides insights into how dynamic protein-protein and protein-membrane interactions may dictate size, shape, and contents of autophagosomes. |
format | Online Article Text |
id | pubmed-4038036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40380362015-04-10 Atomistic Autophagy: The Structures of Cellular Self-Digestion Hurley, James H. Schulman, Brenda A. Cell Article Autophagy is directed by numerous distinct autophagy-related (Atg) proteins. These transmit starvation-induced signals to lipids and regulatory proteins and assemble a double-membrane autophagosome sequestering bulk cytoplasm and/or selected cargos destined for degradation upon autophagosome fusion with a vacuole or lysosome. This Review discusses the structural mechanisms by which Atg proteins sense membrane curvature, mediate a PI(3)P-signaling cascade, and utilize autophagy-specific ubiquitin-like protein cascades to tether proteins to autophagosomal membranes. Recent elucidation of molecular interactions enabling vesicle nucleation, elongation, and cargo recruitment provides insights into how dynamic protein-protein and protein-membrane interactions may dictate size, shape, and contents of autophagosomes. Elsevier Inc. 2014-04-10 2014-04-10 /pmc/articles/PMC4038036/ /pubmed/24725401 http://dx.doi.org/10.1016/j.cell.2014.01.070 Text en Copyright © 2014 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Hurley, James H. Schulman, Brenda A. Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title | Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title_full | Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title_fullStr | Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title_full_unstemmed | Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title_short | Atomistic Autophagy: The Structures of Cellular Self-Digestion |
title_sort | atomistic autophagy: the structures of cellular self-digestion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038036/ https://www.ncbi.nlm.nih.gov/pubmed/24725401 http://dx.doi.org/10.1016/j.cell.2014.01.070 |
work_keys_str_mv | AT hurleyjamesh atomisticautophagythestructuresofcellularselfdigestion AT schulmanbrendaa atomisticautophagythestructuresofcellularselfdigestion |