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Dissecting mammalian immunity through mutation

Although mutation and natural selection have given rise to our immune system, a well-placed mutation can also cripple it, and within an expanding population we are recognizing more and more cases of single-gene mutations that compromise immunity. These mutations are an ideal tool for understanding h...

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Autor principal: Siggs, Owen M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038135/
https://www.ncbi.nlm.nih.gov/pubmed/24518983
http://dx.doi.org/10.1038/icb.2014.8
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author Siggs, Owen M
author_facet Siggs, Owen M
author_sort Siggs, Owen M
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description Although mutation and natural selection have given rise to our immune system, a well-placed mutation can also cripple it, and within an expanding population we are recognizing more and more cases of single-gene mutations that compromise immunity. These mutations are an ideal tool for understanding human immunology, and there are more ways than ever to measure their physiological effects. There are also more ways to create mutations in the laboratory, and to use these resources to systematically define the function of every gene in our genome. This review focuses on the discovery and creation of mutations in the context of mammalian immunity, with an emphasis on the use of genome-wide chemical and CRISPR/Cas9 mutagenesis to reveal gene function.
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spelling pubmed-40381352014-05-30 Dissecting mammalian immunity through mutation Siggs, Owen M Immunol Cell Biol Review Although mutation and natural selection have given rise to our immune system, a well-placed mutation can also cripple it, and within an expanding population we are recognizing more and more cases of single-gene mutations that compromise immunity. These mutations are an ideal tool for understanding human immunology, and there are more ways than ever to measure their physiological effects. There are also more ways to create mutations in the laboratory, and to use these resources to systematically define the function of every gene in our genome. This review focuses on the discovery and creation of mutations in the context of mammalian immunity, with an emphasis on the use of genome-wide chemical and CRISPR/Cas9 mutagenesis to reveal gene function. Nature Publishing Group 2014-05 2014-02-11 /pmc/articles/PMC4038135/ /pubmed/24518983 http://dx.doi.org/10.1038/icb.2014.8 Text en Copyright © 2014 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Review
Siggs, Owen M
Dissecting mammalian immunity through mutation
title Dissecting mammalian immunity through mutation
title_full Dissecting mammalian immunity through mutation
title_fullStr Dissecting mammalian immunity through mutation
title_full_unstemmed Dissecting mammalian immunity through mutation
title_short Dissecting mammalian immunity through mutation
title_sort dissecting mammalian immunity through mutation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038135/
https://www.ncbi.nlm.nih.gov/pubmed/24518983
http://dx.doi.org/10.1038/icb.2014.8
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