Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III

[Image: see text] While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an...

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Autores principales: de Messieres, Michel, Huang, Rick K., He, Yi, Lee, Jennifer C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038341/
https://www.ncbi.nlm.nih.gov/pubmed/24804986
http://dx.doi.org/10.1021/bi500502d
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author de Messieres, Michel
Huang, Rick K.
He, Yi
Lee, Jennifer C.
author_facet de Messieres, Michel
Huang, Rick K.
He, Yi
Lee, Jennifer C.
author_sort de Messieres, Michel
collection PubMed
description [Image: see text] While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an abundant protein implicated in atherosclerosis, and we show it forms a ribbonlike looped amyloid, strikingly similar to that previously reported for ApoAI and ApoCII. Triangles and squares with a width of ∼50 nm were also observed, which may be a novel form of amyloid or related to previously reported amyloid rings.
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spelling pubmed-40383412015-05-07 Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III de Messieres, Michel Huang, Rick K. He, Yi Lee, Jennifer C. Biochemistry [Image: see text] While a significant component of atherosclerotic plaques has been characterized as amyloid, the specific proteins remain to be fully identified. Probable amyloidogenic proteins are apolipoproteins (Apos), which are vital for the formation and function of lipoproteins. ApoCIII is an abundant protein implicated in atherosclerosis, and we show it forms a ribbonlike looped amyloid, strikingly similar to that previously reported for ApoAI and ApoCII. Triangles and squares with a width of ∼50 nm were also observed, which may be a novel form of amyloid or related to previously reported amyloid rings. American Chemical Society 2014-05-07 2014-05-27 /pmc/articles/PMC4038341/ /pubmed/24804986 http://dx.doi.org/10.1021/bi500502d Text en Copyright © 2014 U.S. Government
spellingShingle de Messieres, Michel
Huang, Rick K.
He, Yi
Lee, Jennifer C.
Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title_full Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title_fullStr Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title_full_unstemmed Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title_short Amyloid Triangles, Squares, and Loops of Apolipoprotein C-III
title_sort amyloid triangles, squares, and loops of apolipoprotein c-iii
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038341/
https://www.ncbi.nlm.nih.gov/pubmed/24804986
http://dx.doi.org/10.1021/bi500502d
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AT heyi amyloidtrianglessquaresandloopsofapolipoproteinciii
AT leejenniferc amyloidtrianglessquaresandloopsofapolipoproteinciii

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