Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway

Dysregulation of Sonic hedgehog (Shh) signaling has been implicated in glioma pathogenesis. Yet, the role of this pathway in gliomagenesis remains controversial because of the lack of relevant animal models. Using the cytokeratin 5 promoter, we ectopically expressed a constitutively active zebrafish...

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Detalles Bibliográficos
Autores principales: Ju, B, Chen, W, Spitsbergen, J M, Lu, J, Vogel, P, Peters, J L, Wang, Y-D, Orr, B A, Wu, J, Henson, H E, Jia, S, Parupalli, C, Taylor, M R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038393/
https://www.ncbi.nlm.nih.gov/pubmed/24686726
http://dx.doi.org/10.1038/oncsis.2014.10

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