Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature

Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive ch...

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Autores principales: Dirani, Ali, Matet, Alexandre, Beydoun, Talal, Mantel, Irmela, Behar-Cohen, Francine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038426/
https://www.ncbi.nlm.nih.gov/pubmed/24899797
http://dx.doi.org/10.2147/OPTH.S62267
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author Dirani, Ali
Matet, Alexandre
Beydoun, Talal
Mantel, Irmela
Behar-Cohen, Francine
author_facet Dirani, Ali
Matet, Alexandre
Beydoun, Talal
Mantel, Irmela
Behar-Cohen, Francine
author_sort Dirani, Ali
collection PubMed
description Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist.
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spelling pubmed-40384262014-06-04 Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature Dirani, Ali Matet, Alexandre Beydoun, Talal Mantel, Irmela Behar-Cohen, Francine Clin Ophthalmol Case Series Dome-shaped macula (DSM) was recently described in myopic patients as a convex protrusion of the macula within a posterior pole staphyloma. The pathogenesis of DSM and the development of associated serous foveal detachment (SFD) remain unclear. The obstruction of choroidal outflow and compressive changes of choroidal capillaries have been proposed as causative factors. In this paper, we report two cases of patients with chronic SFD associated with DSM treated with oral spironolactone. After treatment, there was a complete resolution of SFD in both patients. To the best of our knowledge, this is the first report of successful treatment of SFD in DSM by a mineralocorticoid receptor antagonist. Dove Medical Press 2014-05-20 /pmc/articles/PMC4038426/ /pubmed/24899797 http://dx.doi.org/10.2147/OPTH.S62267 Text en © 2014 Dirani et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Series
Dirani, Ali
Matet, Alexandre
Beydoun, Talal
Mantel, Irmela
Behar-Cohen, Francine
Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_full Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_fullStr Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_full_unstemmed Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_short Resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
title_sort resolution of foveal detachment in dome-shaped macula after treatment by spironolactone: report of two cases and mini-review of the literature
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038426/
https://www.ncbi.nlm.nih.gov/pubmed/24899797
http://dx.doi.org/10.2147/OPTH.S62267
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