SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates

Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC) patients causes benign cartilage tumors on the bone surface (exostoses) and within bones (enchondromas). To elucidate the mechanisms underlying cartilage tumor formation, we investigated the role of SHP2 in the specification, maturation...

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Detalles Bibliográficos
Autores principales: Bowen, Margot E., Ayturk, Ugur M., Kurek, Kyle C., Yang, Wentian, Warman, Matthew L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038465/
https://www.ncbi.nlm.nih.gov/pubmed/24875294
http://dx.doi.org/10.1371/journal.pgen.1004364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038465/
https://www.ncbi.nlm.nih.gov/pubmed/24875294
http://dx.doi.org/10.1371/journal.pgen.1004364

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