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Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis

PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU. METHODS: T...

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Autores principales: Jiménez-Balderas, Francisco-Javier, García-Jaimes, Janete, Ríos, Rita, Zonana-Nacach, Abraham, Tapia-Romero, Raquel, Villanueva, Nayeli, Méndez-Samperio, Patricia, de-la-Rosa-Arana, Jorge-Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Ophthalmological Society 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038725/
https://www.ncbi.nlm.nih.gov/pubmed/24882953
http://dx.doi.org/10.3341/kjo.2014.28.3.207
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author Jiménez-Balderas, Francisco-Javier
García-Jaimes, Janete
Ríos, Rita
Zonana-Nacach, Abraham
Tapia-Romero, Raquel
Villanueva, Nayeli
Méndez-Samperio, Patricia
de-la-Rosa-Arana, Jorge-Luis
author_facet Jiménez-Balderas, Francisco-Javier
García-Jaimes, Janete
Ríos, Rita
Zonana-Nacach, Abraham
Tapia-Romero, Raquel
Villanueva, Nayeli
Méndez-Samperio, Patricia
de-la-Rosa-Arana, Jorge-Luis
author_sort Jiménez-Balderas, Francisco-Javier
collection PubMed
description PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU. METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions. RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS. CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.
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spelling pubmed-40387252014-06-01 Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis Jiménez-Balderas, Francisco-Javier García-Jaimes, Janete Ríos, Rita Zonana-Nacach, Abraham Tapia-Romero, Raquel Villanueva, Nayeli Méndez-Samperio, Patricia de-la-Rosa-Arana, Jorge-Luis Korean J Ophthalmol Original Article PURPOSE: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS) patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine the presence of antibodies against Toxocara canis in AS patients with ANGAU. METHODS: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAU was accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determined by enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were also tested to verify non-specific reactions. RESULTS: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients with ANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positive for T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens in the serum samples of patients with AS. CONCLUSIONS: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patients with AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated with the pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation. The Korean Ophthalmological Society 2014-06 2014-05-19 /pmc/articles/PMC4038725/ /pubmed/24882953 http://dx.doi.org/10.3341/kjo.2014.28.3.207 Text en © 2014 The Korean Ophthalmological Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jiménez-Balderas, Francisco-Javier
García-Jaimes, Janete
Ríos, Rita
Zonana-Nacach, Abraham
Tapia-Romero, Raquel
Villanueva, Nayeli
Méndez-Samperio, Patricia
de-la-Rosa-Arana, Jorge-Luis
Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title_full Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title_fullStr Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title_full_unstemmed Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title_short Isolation of IgG Antibodies to Toxocara in Ankylosing Spondylitis Patients with Acute Anterior Uveitis
title_sort isolation of igg antibodies to toxocara in ankylosing spondylitis patients with acute anterior uveitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038725/
https://www.ncbi.nlm.nih.gov/pubmed/24882953
http://dx.doi.org/10.3341/kjo.2014.28.3.207
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