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Intramedullary melanocytoma of thoracic spine: A rare case report
Melanocytomas are present in leptomeninges and arise from neural crest during early embryonic development. They are a rare entity and usually occur in the thoracic spine and infratentorial region. We report a 32-year-old female with meningeal melanocytoma of D9-10. Magnetic resonance imaging reveale...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038865/ https://www.ncbi.nlm.nih.gov/pubmed/24891889 http://dx.doi.org/10.4103/1793-5482.131068 |
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author | Dorwal, Pranav Mohapatra, Ishani Gautam, Dheeraj Gupta, Aditya |
author_facet | Dorwal, Pranav Mohapatra, Ishani Gautam, Dheeraj Gupta, Aditya |
author_sort | Dorwal, Pranav |
collection | PubMed |
description | Melanocytomas are present in leptomeninges and arise from neural crest during early embryonic development. They are a rare entity and usually occur in the thoracic spine and infratentorial region. We report a 32-year-old female with meningeal melanocytoma of D9-10. Magnetic resonance imaging revealed an intramedullary spinal tumor at D9-D10. Intraoperatively, the tumor was greyish-black in color with moderate vascularity, and was adherent to the cord. The clinical differential diagnoses included cavernoma and melanocytoma. On microscopic examination, the lesion showed sheets of cells with marked pigment deposition, which was obscuring the cellular morphology. The pigment was confirmed to be melanin by Masson's Fontana stain. Immunohistochemistry was performed, which showed positivity for HMB-45, S-100, Vimentin and Melan-A. The cells were negative for cytokeratin, epithelial membrane antigen, Glial fibrillary acidic protein and neuron-specific enolase. Mib-1 labeling index was less than 1%. In view of the lack of nuclear atypia, mitoses, necrosis and low Mib-1-labeling index along with immunohistochemistry profile, the diagnosis of Melanocytoma was made. Melanocytomas are rare pigmented tumors of the spinal cord and posterior cranial fossa. They are benign in nature, but can also be locally aggressive. Melanocytic lesions of the nervous system are to be differentiated from metastatic melanomas and also tumors showing melanin pigment deposition like schwanomma, paraganglioma, medulloblastoma and various gliomas. |
format | Online Article Text |
id | pubmed-4038865 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40388652014-06-02 Intramedullary melanocytoma of thoracic spine: A rare case report Dorwal, Pranav Mohapatra, Ishani Gautam, Dheeraj Gupta, Aditya Asian J Neurosurg Case Report Melanocytomas are present in leptomeninges and arise from neural crest during early embryonic development. They are a rare entity and usually occur in the thoracic spine and infratentorial region. We report a 32-year-old female with meningeal melanocytoma of D9-10. Magnetic resonance imaging revealed an intramedullary spinal tumor at D9-D10. Intraoperatively, the tumor was greyish-black in color with moderate vascularity, and was adherent to the cord. The clinical differential diagnoses included cavernoma and melanocytoma. On microscopic examination, the lesion showed sheets of cells with marked pigment deposition, which was obscuring the cellular morphology. The pigment was confirmed to be melanin by Masson's Fontana stain. Immunohistochemistry was performed, which showed positivity for HMB-45, S-100, Vimentin and Melan-A. The cells were negative for cytokeratin, epithelial membrane antigen, Glial fibrillary acidic protein and neuron-specific enolase. Mib-1 labeling index was less than 1%. In view of the lack of nuclear atypia, mitoses, necrosis and low Mib-1-labeling index along with immunohistochemistry profile, the diagnosis of Melanocytoma was made. Melanocytomas are rare pigmented tumors of the spinal cord and posterior cranial fossa. They are benign in nature, but can also be locally aggressive. Melanocytic lesions of the nervous system are to be differentiated from metastatic melanomas and also tumors showing melanin pigment deposition like schwanomma, paraganglioma, medulloblastoma and various gliomas. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4038865/ /pubmed/24891889 http://dx.doi.org/10.4103/1793-5482.131068 Text en Copyright: © Asian Journal of Neurosurgery http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Dorwal, Pranav Mohapatra, Ishani Gautam, Dheeraj Gupta, Aditya Intramedullary melanocytoma of thoracic spine: A rare case report |
title | Intramedullary melanocytoma of thoracic spine: A rare case report |
title_full | Intramedullary melanocytoma of thoracic spine: A rare case report |
title_fullStr | Intramedullary melanocytoma of thoracic spine: A rare case report |
title_full_unstemmed | Intramedullary melanocytoma of thoracic spine: A rare case report |
title_short | Intramedullary melanocytoma of thoracic spine: A rare case report |
title_sort | intramedullary melanocytoma of thoracic spine: a rare case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038865/ https://www.ncbi.nlm.nih.gov/pubmed/24891889 http://dx.doi.org/10.4103/1793-5482.131068 |
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