Aberrant regulation of FBW7 in cancer

FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EB...

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Detalles Bibliográficos
Autores principales: Wang, Lixia, Ye, Xiantao, Liu, Yueyong, Wei, Wenyi, Wang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039140/
https://www.ncbi.nlm.nih.gov/pubmed/24899581
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author Wang, Lixia
Ye, Xiantao
Liu, Yueyong
Wei, Wenyi
Wang, Zhiwei
author_facet Wang, Lixia
Ye, Xiantao
Liu, Yueyong
Wei, Wenyi
Wang, Zhiwei
author_sort Wang, Lixia
collection PubMed
description FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EBP2, Pin1, Hes-5 and Numb4 as well as by microRNAs such as miR-223, miR-27a, miR-25, and miR-129-5p. Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy.
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spelling pubmed-40391402014-06-10 Aberrant regulation of FBW7 in cancer Wang, Lixia Ye, Xiantao Liu, Yueyong Wei, Wenyi Wang, Zhiwei Oncotarget Review FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EBP2, Pin1, Hes-5 and Numb4 as well as by microRNAs such as miR-223, miR-27a, miR-25, and miR-129-5p. Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy. Impact Journals LLC 2014-03-25 /pmc/articles/PMC4039140/ /pubmed/24899581 Text en Copyright: © 2014 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wang, Lixia
Ye, Xiantao
Liu, Yueyong
Wei, Wenyi
Wang, Zhiwei
Aberrant regulation of FBW7 in cancer
title Aberrant regulation of FBW7 in cancer
title_full Aberrant regulation of FBW7 in cancer
title_fullStr Aberrant regulation of FBW7 in cancer
title_full_unstemmed Aberrant regulation of FBW7 in cancer
title_short Aberrant regulation of FBW7 in cancer
title_sort aberrant regulation of fbw7 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039140/
https://www.ncbi.nlm.nih.gov/pubmed/24899581
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AT yexiantao aberrantregulationoffbw7incancer
AT liuyueyong aberrantregulationoffbw7incancer
AT weiwenyi aberrantregulationoffbw7incancer
AT wangzhiwei aberrantregulationoffbw7incancer

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