MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

While MDM2 inhibitors hold great promise as cancer therapeutics, drug resistance will likely limit their efficacy as single agents. To identify drug combinations that might circumvent resistance, we screened for agents that could synergize with MDM2 inhibition in the suppression of cell viability. W...

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Detalles Bibliográficos
Autores principales: Saiki, Anne Y., Caenepeel, Sean, Yu, Dongyin, Lofgren, Julie A., Osgood, Tao, Robertson, Rebecca, Canon, Jude, Su, Cheng, Jones, Adrie, Zhao, Xiaoning, Deshpande, Chetan, Payton, Marc, Ledell, Jebediah, Hughes, Paul E., Oliner, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039142/
https://www.ncbi.nlm.nih.gov/pubmed/24810962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039142/
https://www.ncbi.nlm.nih.gov/pubmed/24810962

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