Next-Generation Sequencing of RNA and DNA Isolated from Paired Fresh-Frozen and Formalin-Fixed Paraffin-Embedded Samples of Human Cancer and Normal Tissue

Formalin-fixed, paraffin-embedded (FFPE) tissues are an invaluable resource for clinical research. However, nucleic acids extracted from FFPE tissues are fragmented and chemically modified making them challenging to use in molecular studies. We analysed 23 fresh-frozen (FF), 35 FFPE and 38 paired FF...

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Detalles Bibliográficos
Autores principales: Hedegaard, Jakob, Thorsen, Kasper, Lund, Mette Katrine, Hein, Anne-Mette K., Hamilton-Dutoit, Stephen Jacques, Vang, Søren, Nordentoft, Iver, Birkenkamp-Demtröder, Karin, Kruhøffer, Mogens, Hager, Henrik, Knudsen, Bjarne, Andersen, Claus Lindbjerg, Sørensen, Karina Dalsgaard, Pedersen, Jakob Skou, Ørntoft, Torben Falck, Dyrskjøt, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039489/
https://www.ncbi.nlm.nih.gov/pubmed/24878701
http://dx.doi.org/10.1371/journal.pone.0098187

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