Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation

PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated wit...

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Detalles Bibliográficos
Autores principales: Leal, Mariana Ferreira, Cirilo, Priscila Daniele Ramos, Mazzotti, Tatiane Katsue Furuya, Calcagno, Danielle Queiroz, Wisnieski, Fernanda, Demachki, Samia, Martinez, Margarita Cortes, Assumpção, Paulo Pimentel, Chammas, Roger, Burbano, Rommel Rodríguez, Smith, Marília Cardoso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039508/
https://www.ncbi.nlm.nih.gov/pubmed/24879411
http://dx.doi.org/10.1371/journal.pone.0098583
Descripción
Sumario:PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.

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