Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation

PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated wit...

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Autores principales: Leal, Mariana Ferreira, Cirilo, Priscila Daniele Ramos, Mazzotti, Tatiane Katsue Furuya, Calcagno, Danielle Queiroz, Wisnieski, Fernanda, Demachki, Samia, Martinez, Margarita Cortes, Assumpção, Paulo Pimentel, Chammas, Roger, Burbano, Rommel Rodríguez, Smith, Marília Cardoso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039508/
https://www.ncbi.nlm.nih.gov/pubmed/24879411
http://dx.doi.org/10.1371/journal.pone.0098583
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author Leal, Mariana Ferreira
Cirilo, Priscila Daniele Ramos
Mazzotti, Tatiane Katsue Furuya
Calcagno, Danielle Queiroz
Wisnieski, Fernanda
Demachki, Samia
Martinez, Margarita Cortes
Assumpção, Paulo Pimentel
Chammas, Roger
Burbano, Rommel Rodríguez
Smith, Marília Cardoso
author_facet Leal, Mariana Ferreira
Cirilo, Priscila Daniele Ramos
Mazzotti, Tatiane Katsue Furuya
Calcagno, Danielle Queiroz
Wisnieski, Fernanda
Demachki, Samia
Martinez, Margarita Cortes
Assumpção, Paulo Pimentel
Chammas, Roger
Burbano, Rommel Rodríguez
Smith, Marília Cardoso
author_sort Leal, Mariana Ferreira
collection PubMed
description PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation.
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spelling pubmed-40395082014-06-02 Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation Leal, Mariana Ferreira Cirilo, Priscila Daniele Ramos Mazzotti, Tatiane Katsue Furuya Calcagno, Danielle Queiroz Wisnieski, Fernanda Demachki, Samia Martinez, Margarita Cortes Assumpção, Paulo Pimentel Chammas, Roger Burbano, Rommel Rodríguez Smith, Marília Cardoso PLoS One Research Article PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced PHB mRNA levels. Moreover, the up-regulation of PHB appeared to be regulated by the gain of additional gene copies. Thus, PHB copy number variation and differential expression of the rs6917 polymorphism may play a role in PHB transcriptional regulation. Public Library of Science 2014-05-30 /pmc/articles/PMC4039508/ /pubmed/24879411 http://dx.doi.org/10.1371/journal.pone.0098583 Text en © 2014 Leal et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Leal, Mariana Ferreira
Cirilo, Priscila Daniele Ramos
Mazzotti, Tatiane Katsue Furuya
Calcagno, Danielle Queiroz
Wisnieski, Fernanda
Demachki, Samia
Martinez, Margarita Cortes
Assumpção, Paulo Pimentel
Chammas, Roger
Burbano, Rommel Rodríguez
Smith, Marília Cardoso
Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title_full Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title_fullStr Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title_full_unstemmed Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title_short Prohibitin Expression Deregulation in Gastric Cancer Is Associated with the 3′ Untranslated Region 1630 C>T Polymorphism and Copy Number Variation
title_sort prohibitin expression deregulation in gastric cancer is associated with the 3′ untranslated region 1630 c>t polymorphism and copy number variation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039508/
https://www.ncbi.nlm.nih.gov/pubmed/24879411
http://dx.doi.org/10.1371/journal.pone.0098583
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